Strong association of interleukin-6 -174 G>C promoter polymorphism with increased risk of oral cancer

In view of the recently found contribution of factors associated with thrombosis and inflammation to carcinogenesis, we investigated the possible association of interleukin-6 (IL-6) with an increased risk of oral cancer. In DNA samples of 162 patients with oral squamous cell carcinoma and 156 health...

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Published in:The International journal of biological markers 2006-10, Vol.21 (4), p.246-250
Main Authors: VAIRAKTARIS, E, YIANNOPOULOS, A, VORRIS, E, CRITSELIS, E, AVGOUSTIDIS, D, NEUKAM, F. W, PATSOURIS, E, VYLLIOTIS, A, YAPIJAKIS, C, DERKA, S, VASSILIOU, S, NKENKE, E, SEREFOGLOU, Z, RAGOS, V, TSIGRIS, C
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-6 - genetics
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Mouth Neoplasms - etiology
Mouth Neoplasms - genetics
Polymorphism, Genetic
Promoter Regions, Genetic
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Summary:In view of the recently found contribution of factors associated with thrombosis and inflammation to carcinogenesis, we investigated the possible association of interleukin-6 (IL-6) with an increased risk of oral cancer. In DNA samples of 162 patients with oral squamous cell carcinoma and 156 healthy controls of comparable ethnicity, age and sex, we studied the -174 G>C polymorphism in the IL-6 gene, which affects its transcription. C allele frequencies were significantly increased in patients compared to controls, 42.6% versus 23.1% (p
ISSN:0393-6155
1724-6008
DOI:10.1177/172460080602100409