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Plasma vasopressin response to hypertonic saline infusion to assess posterior pituitary function
Hypertonic saline was infused into 11 volunteers to osmotically stimulate vasopressin secretion. A strong positive correlation between plasma arginine vasopressin (PAVP) and plasma osmolality (Pos) was obtained, defined by the function PAVP=0.63 (Pos-284), r=+0.80, P
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Published in: | Journal of the Royal Society of Medicine 1980-04, Vol.73 (4), p.255-260 |
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container_title | Journal of the Royal Society of Medicine |
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creator | Baylis, P H Robertson, G L |
description | Hypertonic saline was infused into 11 volunteers to osmotically stimulate vasopressin secretion. A strong positive correlation between plasma arginine vasopressin (PAVP) and plasma osmolality (Pos) was obtained, defined by the function PAVP=0.63 (Pos-284), r=+0.80, P |
doi_str_mv | 10.1177/014107688007300408 |
format | article |
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A strong positive correlation between plasma arginine vasopressin (PAVP) and plasma osmolality (Pos) was obtained, defined by the function PAVP=0.63 (Pos-284), r=+0.80, P<0.001. The sensitivity of vasopressin secretion to osmotic stimulation was represented by the slope of the expression and the theoretical threshold of vasopressin release by the abscissal intercept. Plasma osmolality at the onset of thirst was 298.5±1.1 mmol/kg. Application of hypertonic saline infusion to 10 polyuric patients clearly separated those with normal osmoregulation of vasopressin secretion from those with cranial diabetes insipidus.</description><identifier>ISSN: 0141-0768</identifier><identifier>EISSN: 1758-1095</identifier><identifier>DOI: 10.1177/014107688007300408</identifier><identifier>PMID: 7241442</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Arginine Vasopressin - blood ; Female ; Humans ; Male ; Middle Aged ; Osmolar Concentration ; Pituitary Gland, Posterior - physiology ; Pituitary Gland, Posterior - physiopathology ; Polyuria - physiopathology ; Regression Analysis ; Saline Solution, Hypertonic ; Sodium Chloride</subject><ispartof>Journal of the Royal Society of Medicine, 1980-04, Vol.73 (4), p.255-260</ispartof><rights>1980 The Royal Society of Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-49becd561d093283d6be70bd6b733783ce3fca0b222b8b1ca6290a21e22f67803</citedby><cites>FETCH-LOGICAL-c397t-49becd561d093283d6be70bd6b733783ce3fca0b222b8b1ca6290a21e22f67803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1437414/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1437414/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7241442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baylis, P H</creatorcontrib><creatorcontrib>Robertson, G L</creatorcontrib><title>Plasma vasopressin response to hypertonic saline infusion to assess posterior pituitary function</title><title>Journal of the Royal Society of Medicine</title><addtitle>J R Soc Med</addtitle><description>Hypertonic saline was infused into 11 volunteers to osmotically stimulate vasopressin secretion. A strong positive correlation between plasma arginine vasopressin (PAVP) and plasma osmolality (Pos) was obtained, defined by the function PAVP=0.63 (Pos-284), r=+0.80, P<0.001. The sensitivity of vasopressin secretion to osmotic stimulation was represented by the slope of the expression and the theoretical threshold of vasopressin release by the abscissal intercept. Plasma osmolality at the onset of thirst was 298.5±1.1 mmol/kg. Application of hypertonic saline infusion to 10 polyuric patients clearly separated those with normal osmoregulation of vasopressin secretion from those with cranial diabetes insipidus.</description><subject>Adult</subject><subject>Arginine Vasopressin - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osmolar Concentration</subject><subject>Pituitary Gland, Posterior - physiology</subject><subject>Pituitary Gland, Posterior - physiopathology</subject><subject>Polyuria - physiopathology</subject><subject>Regression Analysis</subject><subject>Saline Solution, Hypertonic</subject><subject>Sodium Chloride</subject><issn>0141-0768</issn><issn>1758-1095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><recordid>eNplkUtLxDAUhYMoOj7-gCBk5a6aV5t0I4j4AkEXuo5pJnUinaTmpoL_3gwOg-LqEO53Ti73IHRMyRmlUp4TKiiRjVKESE6IIGoLzaisVUVJW2-j2QqoVsQe2gd4J-XdNnwX7UomqBBshl6fBgNLgz8NxDE5AB9wkTEGcDhHvPgaXcoxeIvBDD447EM_gY9hNTUAxYLHCNklHxMefZ58NukL91OwuWCHaKc3A7ijtR6gl5vr56u76uHx9v7q8qGyvJW5Em3n7Lxu6Jy0nCk-bzonSVdEci4Vt4731pCOMdapjlrTsJYYRh1jfSMV4Qfo4id3nLqlm1sXcjKDHpNflnV0NF7_nQS_0G_xU1PBZTlGCThdB6T4MTnIeunBumEwwcUJtKyFkkLWBWQ_oE0RILl-8wkletWL_t9LMZ38Xm9jWRfBvwG0SIvc</recordid><startdate>19800401</startdate><enddate>19800401</enddate><creator>Baylis, P H</creator><creator>Robertson, G L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19800401</creationdate><title>Plasma vasopressin response to hypertonic saline infusion to assess posterior pituitary function</title><author>Baylis, P H ; Robertson, G L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-49becd561d093283d6be70bd6b733783ce3fca0b222b8b1ca6290a21e22f67803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adult</topic><topic>Arginine Vasopressin - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osmolar Concentration</topic><topic>Pituitary Gland, Posterior - physiology</topic><topic>Pituitary Gland, Posterior - physiopathology</topic><topic>Polyuria - physiopathology</topic><topic>Regression Analysis</topic><topic>Saline Solution, Hypertonic</topic><topic>Sodium Chloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baylis, P H</creatorcontrib><creatorcontrib>Robertson, G L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Royal Society of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baylis, P H</au><au>Robertson, G L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma vasopressin response to hypertonic saline infusion to assess posterior pituitary function</atitle><jtitle>Journal of the Royal Society of Medicine</jtitle><addtitle>J R Soc Med</addtitle><date>1980-04-01</date><risdate>1980</risdate><volume>73</volume><issue>4</issue><spage>255</spage><epage>260</epage><pages>255-260</pages><issn>0141-0768</issn><eissn>1758-1095</eissn><abstract>Hypertonic saline was infused into 11 volunteers to osmotically stimulate vasopressin secretion. A strong positive correlation between plasma arginine vasopressin (PAVP) and plasma osmolality (Pos) was obtained, defined by the function PAVP=0.63 (Pos-284), r=+0.80, P<0.001. The sensitivity of vasopressin secretion to osmotic stimulation was represented by the slope of the expression and the theoretical threshold of vasopressin release by the abscissal intercept. Plasma osmolality at the onset of thirst was 298.5±1.1 mmol/kg. Application of hypertonic saline infusion to 10 polyuric patients clearly separated those with normal osmoregulation of vasopressin secretion from those with cranial diabetes insipidus.</abstract><cop>England</cop><pmid>7241442</pmid><doi>10.1177/014107688007300408</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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source | Free E-Journal (出版社公開部分のみ); PubMed Central |
subjects | Adult Arginine Vasopressin - blood Female Humans Male Middle Aged Osmolar Concentration Pituitary Gland, Posterior - physiology Pituitary Gland, Posterior - physiopathology Polyuria - physiopathology Regression Analysis Saline Solution, Hypertonic Sodium Chloride |
title | Plasma vasopressin response to hypertonic saline infusion to assess posterior pituitary function |
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