TREATMENT OF WHOOPING COUGH AND WHOOPING COUGH SYNDROME BY CEFOPERAZONE

Clinical trial of cefoperazone (CPZ) for the treatment of whooping cough and whooping cough syndrome was performed and the following results were obtained. 1) In 18 cases suffering from whooping cough, CPZ was given 47-106 mg/kg/day (average 72 mg/kg/day) by intravenous route.The clinical efficacy r...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1980/11/25, Vol.33(11), pp.1183-1193
Main Authors: MOTOHIRO, TAKASHI, SAKATA, YASUTAKA, FUJIMOTO, TAMOTSU, NISHIYAMA, TOORU, NAKAJIMA, TETSUYA, ISHIMOTO, KOJI, TOMINAGA, KAORU, YAMASHITA, FUMIO, SHISHIDO, HARUMI, WATANABE, KIWAO, MATSUMOTO, KEIZO, TAZAKI, KEISUKE, OKI, SHIGEMI, ARAKI, HISAAKI, TAKAJO, NOBUHIKO, YUASA, KOU, TANAKA, YOSHIMI, TSUGAWA, SHIN, NAGAYAMA, KIYOTAKA, KOMATSU, RYOJI, YAMAMOTO, MASASHI, OOKITA, RYOSUKE, SAKAGUCHI, YUSUKE, TERASAWA, KENJIRO, KINOSHITA, MASANORI
Format: Article
Language:Japanese
Subjects:
Bordetella pertussis - drug effects
Cefoperazone
Cephalosporins - administration & dosage
Cephalosporins - pharmacology
Cephalosporins - therapeutic use
Child
Child, Preschool
Drug Evaluation
Drug Resistance, Microbial
Female
Humans
Infant
Infant, Newborn
Injections, Intravenous
Male
Whooping Cough - drug therapy
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Summary:Clinical trial of cefoperazone (CPZ) for the treatment of whooping cough and whooping cough syndrome was performed and the following results were obtained. 1) In 18 cases suffering from whooping cough, CPZ was given 47-106 mg/kg/day (average 72 mg/kg/day) by intravenous route.The clinical efficacy rates judged by doctors in charge were 44% on the 3rd day, 75% on the 7th day, 86% on the period day.And in these cases, the clinical efficacy rates judged by committee members were 56%, 83% and 86%. 2) In 6 cases diagnosed as whooping cough syndrome, CPZ was given 49-96 mg/kg/day (average 59mg/kg/day) by the same route.The clinical efficacy rates judged by doctors in charge were 67% on the 3rd day, 80% on the 7th day and 75% on the period day.And in these cases, those judged by committee members were 83%, 80% and 100%. 3) In 1 case, Bordetella pertussis was searched and showed 0.012mcg/ml of MIC.It was eliminated on the 1st day after administration. 4) Doctors in charge judged the utility of CPZ for whooping cough.Twelve cases were useful and 6 cases were slightly useful. 5) No side effects were observed except for elevation of GOT and LDH.These results suggest that CPZ might be useful drug against whooping cough.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.33.1183