Raman Spectroscopy of Bone Mineral Crystallization in a Microfluidic Chip

Bone diseases are a significant human health problem that can benefit from fundamental studies which may lead to improved diagnosis and treatment. Bone is an integrated material in which nano-crystals of carbonated apatite (a calcium phosphate mineral similar to hydroxylapatite Ca(10)(PO(4))(6-x)(CO...

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Bibliographic Details
Main Authors: Tecklenburg, Mary M J, Whitman, Brandon
Format: Conference Proceeding
Language:English
Online Access:Get full text
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Summary:Bone diseases are a significant human health problem that can benefit from fundamental studies which may lead to improved diagnosis and treatment. Bone is an integrated material in which nano-crystals of carbonated apatite (a calcium phosphate mineral similar to hydroxylapatite Ca(10)(PO(4))(6-x)(CO(3))(x)(OH)(2)) crystallizes in the interstices of oriented type I collagen fibrils [1,2]. Non-collagenous proteins represent only 10% of the bone extracelluar matrix yet they seem be crucial to bone mineralization by aiding in matrix organization and mineral formation and growth. Examination of the relationship between non-collagenous proteins and apatite mineralization will lead towards an understanding of normal and diseased mineralization in bone.
ISSN:0094-243X
DOI:10.1063/1.3482589