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Selective effects of aging on brain white matter microstructure: A diffusion tensor imaging tractography study

We examined age-related changes in the cerebral white matter. Structural magnetic resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy subjects aged 22–84years. Quantitative DTI tractography was performed for nine different white matter tracts to determine tract v...

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Published in:	NeuroImage (Orlando, Fla.) Fla.), 2010-10, Vol.52 (4), p.1190-1201
Main Authors:	Michielse, Stijn, Coupland, Nick, Camicioli, Richard, Carter, Rawle, Seres, Peter, Sabino, Jennifer, Malykhin, Nikolai
Format:	Article
Language:	English
Subjects:	Adult Age Aged Aged, 80 and over Aging Aging - pathology Attention deficit hyperactivity disorder Brain Brain - pathology Cerebrospinal fluid Cingulum Corpus callosum Diffusion Diffusion tensor imaging Diffusion Tensor Imaging - methods Female Fornix Gray matter Humans Male Medical research Microstructure Middle Aged MRI Nerve Fibers, Myelinated - ultrastructure Studies Tractography Uncinate fasciculus White matter
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creator	Michielse, Stijn Coupland, Nick Camicioli, Richard Carter, Rawle Seres, Peter Sabino, Jennifer Malykhin, Nikolai
description	We examined age-related changes in the cerebral white matter. Structural magnetic resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy subjects aged 22–84years. Quantitative DTI tractography was performed for nine different white matter tracts to determine tract volume, fractional anisotropy (FA), mean diffusivity (MD), axial, and radial diffusivities. We used automated and manual segmentation to determine volumes of gray matter (GM), white mater (WM), cerebrospinal fluid (CSF), and intracranial space. The results showed significant effects of aging on WM, GM, CSF volumes, and selective effects of aging on structural integrity of different white matter tracts. WM of the prefrontal region was the most vulnerable to aging, while temporal lobe connections, cingulum, and parieto-occipital commissural connections showed relative preservation with age. This study was cross-sectional, and therefore, additional longitudinal studies are needed to confirm our findings.
doi_str_mv	10.1016/j.neuroimage.2010.05.019
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Structural magnetic resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy subjects aged 22–84years. Quantitative DTI tractography was performed for nine different white matter tracts to determine tract volume, fractional anisotropy (FA), mean diffusivity (MD), axial, and radial diffusivities. We used automated and manual segmentation to determine volumes of gray matter (GM), white mater (WM), cerebrospinal fluid (CSF), and intracranial space. The results showed significant effects of aging on WM, GM, CSF volumes, and selective effects of aging on structural integrity of different white matter tracts. WM of the prefrontal region was the most vulnerable to aging, while temporal lobe connections, cingulum, and parieto-occipital commissural connections showed relative preservation with age. 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All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 1, 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-260c63288e9d18a8b626a7cfba353dd6247ff916ceb0f23d72681c6c6c4472fb3</citedby><cites>FETCH-LOGICAL-c499t-260c63288e9d18a8b626a7cfba353dd6247ff916ceb0f23d72681c6c6c4472fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20483378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Michielse, Stijn</creatorcontrib><creatorcontrib>Coupland, Nick</creatorcontrib><creatorcontrib>Camicioli, Richard</creatorcontrib><creatorcontrib>Carter, Rawle</creatorcontrib><creatorcontrib>Seres, Peter</creatorcontrib><creatorcontrib>Sabino, Jennifer</creatorcontrib><creatorcontrib>Malykhin, Nikolai</creatorcontrib><title>Selective effects of aging on brain white matter microstructure: A diffusion tensor imaging tractography study</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>We examined age-related changes in the cerebral white matter. Structural magnetic resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy subjects aged 22–84years. Quantitative DTI tractography was performed for nine different white matter tracts to determine tract volume, fractional anisotropy (FA), mean diffusivity (MD), axial, and radial diffusivities. We used automated and manual segmentation to determine volumes of gray matter (GM), white mater (WM), cerebrospinal fluid (CSF), and intracranial space. The results showed significant effects of aging on WM, GM, CSF volumes, and selective effects of aging on structural integrity of different white matter tracts. WM of the prefrontal region was the most vulnerable to aging, while temporal lobe connections, cingulum, and parieto-occipital commissural connections showed relative preservation with age. 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subjects	Adult Age Aged Aged, 80 and over Aging Aging - pathology Attention deficit hyperactivity disorder Brain Brain - pathology Cerebrospinal fluid Cingulum Corpus callosum Diffusion Diffusion tensor imaging Diffusion Tensor Imaging - methods Female Fornix Gray matter Humans Male Medical research Microstructure Middle Aged MRI Nerve Fibers, Myelinated - ultrastructure Studies Tractography Uncinate fasciculus White matter
title	Selective effects of aging on brain white matter microstructure: A diffusion tensor imaging tractography study
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