Protective effect of Pracparatum mungo extract on carbon tetrachloride-induced hepatotoxicity in rats

Pracparatum mungo is a traditional and functional food in Traditional Chinese Medicine, especially for treating a variety of liver disorders. In this study, we first report the in vivo hepatoprotective effect of P. mungo extract (PME) on carbon tetrachloride (CCl 4)-induced acute hepatotoxicity in r...

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Published in:Food chemistry 2010-12, Vol.123 (4), p.1007-1012
Main Authors: Kuo, Daih-Huang, Kang, Wen-Hsimg, Shieh, Po-Chuen, Chen, Fu-An, Chang, Ching-Dong, Tsai, Mei-Ling, Cheng, An-Chin, Ho, Chi-Tang, Pan, Min-Hsiung
Format: Article
Language:English
Subjects:
Alanine transaminase
animal models
Antioxidant activity
aspartate transaminase
Biological and medical sciences
Carbon tetrachloride
diet
Food industries
Fundamental and applied biological sciences. Psychology
glutathione
hepatoprotective effect
Hepatotoxicity
human diseases
human nutrition
hydroperoxides
lipid peroxidation
liver damage
liver diseases
oxidative stress
plant extracts
Pracparatum mungo
rats
superoxide dismutase
traditional foods
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Summary:Pracparatum mungo is a traditional and functional food in Traditional Chinese Medicine, especially for treating a variety of liver disorders. In this study, we first report the in vivo hepatoprotective effect of P. mungo extract (PME) on carbon tetrachloride (CCl 4)-induced acute hepatotoxicity in rats. Pre-treatment with PME for 56 days significantly reduced the impact of CCl 4 toxicity on the serum markers of liver damage, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The results were confirmed histopathologically. In addition, an increased lipid hydroperoxide (LPO), a decreased glutathione (GSH) concentration and a decreased superoxide dismutase (SOD) were observed in the hepatic tissues. On the contrary, treatment of PME prior to the administration of CCl 4 resulted in markedly decreased lipid peroxidation, increased the levels of GSH and SOD in rats. The results indicated that PME has a protective effect against acute hepatotoxicity induced by the administration of CCl 4 in rats, and that the hepatoprotective effects of PME may be due to both the inhibition of lipid peroxidation and the increase of antioxidant activity.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2010.05.052