Large-scale benchmark of Endeavour using MetaCore maps

Endeavour is a tool that detects the most promising genes within large lists of candidates with respect to a biological process of interest and by combining several genomic data sources. We have benchmarked Endeavour using 450 pathway maps and 826 disease marker sets from MetaCoreTM of GeneGo, Inc....

Full description

Saved in:
Bibliographic Details
Published in:Bioinformatics 2010-08, Vol.26 (15), p.1922-1923
Main Authors: Schuierer, Sven, Tranchevent, Léon-Charles, Dengler, Uwe, Moreau, Yves
Format: Article
Language:English
Subjects:
Benchmarking
Biological and medical sciences
Biomarkers - analysis
Computational Biology - methods
Fundamental and applied biological sciences. Psychology
General aspects
Genes
Genome - genetics
Humans
Internet
Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)
ROC Curve
Software
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endeavour is a tool that detects the most promising genes within large lists of candidates with respect to a biological process of interest and by combining several genomic data sources. We have benchmarked Endeavour using 450 pathway maps and 826 disease marker sets from MetaCoreTM of GeneGo, Inc. containing a total of 9911 and 12 432 genes, respectively. We obtained an area under the receiver operating characteristic curves of 0.97 for pathway and of 0.91 for disease gene sets. These results indicate that Endeavour can be used to efficiently prioritize candidate genes for pathways and diseases. Availability: Endeavour is available at http://www.esat.kuleuven.be/endeavour Contact: sven.schuierer@novartis.com; leon-charles.tranchevent@esat.kuleuven.be Supplementary information: Supplementary data are available at Bioinformatics online.
ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/btq307