An inelastic multi-mechanism constitutive equation for cerebral arterial tissue

Intracranial aneurysms (ICA) are abnormal saccular dilations of cerebral arteries, commonly found at apices of arterial bifurcations and outer walls of curved arterial segments. Histological evidence suggests the stages in ICA development include the deformation of a segment of arterial wall into a...

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Bibliographic Details
Published in:Biomechanics and modeling in mechanobiology 2005-12, Vol.4 (4), p.235-248
Main Authors: Wulandana, R, Robertson, A M
Format: Article
Language:English
Subjects:
Aneurysms
Animals
Biomechanics
Blood Flow Velocity - physiology
Blood Pressure - physiology
Cerebral Arteries - physiology
Computer Simulation
Elasticity
Fibers
Humans
Mechanotransduction, Cellular - physiology
Models, Cardiovascular
Space life sciences
Thromboembolism
Vascular Resistance - physiology
Viscosity
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Summary:Intracranial aneurysms (ICA) are abnormal saccular dilations of cerebral arteries, commonly found at apices of arterial bifurcations and outer walls of curved arterial segments. Histological evidence suggests the stages in ICA development include the deformation of a segment of arterial wall into a "bleb" with no identifiable neck region followed by the development of an aneurysm with a clear neck. Afterwards, the aneurysm may undergo further enlargement, possibly with significant biological response including calcification and thrombosis. Past studies of the biomechanics of cerebral aneurysm tissue have been directed at modeling elastic deformations of pre-existing aneurysms. Taking this approach, the aneurysm wall is treated as a different entity than the arterial tissue from which it developed. In the current work, a nonlinear, inelastic, dual-mechanism constitutive equation for cerebral arterial tissue is developed. It is the first to model the recruitment of collagen fibers and degradation of the internal elastic lamina, two important characteristics of early stage aneurysm formation.
ISSN:1617-7959
1617-7940
DOI:10.1007/s10237-005-0004-z