Analysis of repeated events

Events that may occur repeatedly for individual subjects are of interest in many medical studies. We review methods of analysis for repeated events, emphasizing that the approach taken in a given study should allow clinical questions to be addressed as directly as possible. Methods based on full mod...

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Bibliographic Details
Published in:Statistical methods in medical research 2002-04, Vol.11 (2), p.141-166
Main Authors: Cook, R J, Lawless, J F
Format: Article
Language:English
Subjects:
Asthma - drug therapy
Asthma - physiopathology
Biometry
Bone Neoplasms - secondary
Cystic Fibrosis - complications
Cystic Fibrosis - drug therapy
Humans
Hydrocephalus - surgery
Life Change Events
Lung Diseases - etiology
Lung Diseases - prevention & control
Medical research
Models, Biological
Poisson Distribution
Recurrence
Recurrent events
Statistical analysis
Treatment Failure
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Summary:Events that may occur repeatedly for individual subjects are of interest in many medical studies. We review methods of analysis for repeated events, emphasizing that the approach taken in a given study should allow clinical questions to be addressed as directly as possible. Methods based on full models for event processes as well as on simpler ‘marginal’ assumptions are considered. The treatment of dependent terminating events related to the recurrent events is also discussed. We apply various methods of analysis to studies involving pulmonary exacerbations in persons with cystic fibrosis, and the occurrence of bone metastases and skeletal events in cancer patients, respectively. Most of the methodology considered can be implemented with existing software.
ISSN:0962-2802
1477-0334
DOI:10.1191/0962280202sm278ra