Cytocompatibility of surface ground PE doped with calcium salt of 6-carboxycellulose

We studied the physical–chemical properties of polyethylene (PE) films doped with calcium salt of 6-carboxycellulose (Ca-oxy) in concentrations 0–20 wt.% and their interactions with cells. The interaction between the PE/Ca-oxy composite film and 3T3 cells has not been described so far. Modification...

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Bibliographic Details
Published in:Cellulose (London) 2008-06, Vol.15 (3), p.473-479
Main Authors: Mikulíková, Regina, Švorčík, Václav, Náhlík, Josef, Sopuch, Tomáš, Havelka, Pavel
Format: Article
Language:English
Subjects:
Adhesion tests
Biocompatibility
Bioorganic Chemistry
Calcium
Ceramics
Chemical properties
Chemistry
Chemistry and Materials Science
Composites
Contact angle
Doped films
Fibroblasts
Glass
Morphology
Natural Materials
Organic Chemistry
Physical Chemistry
Polyethylenes
Polymer Sciences
Substrates
Surface grinding
Sustainable Development
Ultrasonic testing
Wettability
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Summary:We studied the physical–chemical properties of polyethylene (PE) films doped with calcium salt of 6-carboxycellulose (Ca-oxy) in concentrations 0–20 wt.% and their interactions with cells. The interaction between the PE/Ca-oxy composite film and 3T3 cells has not been described so far. Modification by surface grinding to enhance material cytocompatibility was studied. The surface wettability of doped films was tested by contact angle measurements and the surface morphology by SEM microscopy and profilometry. Adhesion and proliferation of tissue cells (3T3 mouse fibroblasts) were studied in vitro on pristine and ground doped PE films. The ground samples have a higher contact angle values and the number of proliferated cells is greater on the ground samples than on pristine ones. The presence of Ca-oxy in PE film increases the adhesion of 3T3 cells on the doped substrate and on ground samples adhere more cells than on pristine ones.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-007-9196-y