Basal plasma concentrations of plant sterols can predict LDL-C response to sitosterol in patients with familial hypercholesterolemia

• Published in: European journal of clinical nutrition 2008-04, Vol.62 (4), p.495-501
• Main Authors: Fuentes, F, López-Miranda, J, Garcia, A, Perez-Martinez, P, Moreno, J, Cofan, M, Caballero, J, Paniagua, J.A, Ros, E, Perez-Jimenez, F
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; blood chemistry; blood plasma; Cardiovascular disease; Cardiovascular diseases; chemical concentration; Cholesterol; Cholesterol, LDL; Cholesterol, LDL - blood; Cholesterol, LDL - drug effects; Clinical Nutrition; Combined Modality Therapy; Coronary artery disease; Cross-Over Studies; Diet; Diet therapy; Diet, Fat-Restricted; Disease management; Disorders of blood lipids. Hyperlipoproteinemia; Drug therapy; endothelial cells; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Epidemiology; Feeding. Feeding behavior; Female; Food plants; Fundamental and applied biological sciences. Psychology; Health aspects; Heart diseases; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II - blood; Hyperlipoproteinemia Type II - drug therapy; hypolipidemia; Hypolipidemic Agents - blood; Hypolipidemic Agents - therapeutic use; Internal Medicine; Intervention; Lipids; Low density lipoprotein; Male; medical history; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Nutrient deficiency; Nutrition; nutritional intervention; original-article; Particle Size; Patients; Phytochemicals; Phytosterols; Phytosterols - administration & dosage; Phytosterols - blood; prediction; Predictive Value of Tests; Properties; Public Health; risk factors; sitosterols; Sitosterols - blood; Sitosterols - therapeutic use; Sterols; Treatment Outcome; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/sj.ejcn.1602731

Background: Familial hypercholesterolemia (FH) is associated with a high risk of coronary heart disease. Pharmacological treatment and diet are both essential for the management of FH. Foods rich in plant sterols (PS) may play an important role in the treatment of patients with these disorders. Objective: To test the effect of the intake of PS on low-density lipoprotein (LDL) concentration, endothelial function (EF) and LDL particle size in 30 patients with FH. Design: Randomized and crossover dietary intervention study. Setting: Tertiary outpatient care. Subjects: Thirty-eight were recruited, but only 30 were subjected to four low-fat dietary intervention periods, each of 4 weeks. Methods: Each intervention had a different content of cholesterol (