Effect of a high-protein, high-salt diet on calcium and bone metabolism in postmenopausal women stratified by hormone replacement therapy use

• Published in: European journal of clinical nutrition 2004-10, Vol.58 (10), p.1436-1439
• Main Authors: Harrington, M, Bennett, T, Jakobsen, J, Oveson, L, Brot, C, Flynn, A, Cashman, K.D
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; biomarkers; Bone and Bones - metabolism; Bone resorption; Bone turnover; Bones; Calcium; Calcium (urinary); Calcium - blood; Calcium - metabolism; Calcium - urine; Calcium, Dietary - administration & dosage; Calcium, Dietary - metabolism; calciuric diet; Cholecalciferol - blood; Clinical Nutrition; Collagen; Cross-linking; Cross-Over Studies; Diet; Dietary Proteins - administration & dosage; Dose-Response Relationship, Drug; drug therapy; Epidemiology; excretion; Female; food intake; Gynecology. Andrology. Obstetrics; High protein diet; high sodium diet; hormonal regulation; Hormone Replacement Therapy; Humans; Internal Medicine; Medical sciences; Medicine; Medicine & Public Health; Menopause; Metabolic Diseases; Metabolism; Middle Aged; middle-aged adults; mineral metabolism; Nitrogen; Nitrogen - urine; Parathyroid Hormone - blood; Post-menopause; postmenopausal women; Postmenopause; Protein turnover; Proteins; Puberal and climacteric disorders (male and female); Public Health; Salt; short-communication; Sodium; sodium chloride; Sodium, Dietary - administration & dosage; Sodium, Dietary - blood; Sodium, Dietary - urine; Women
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/sj.ejcn.1601983

The objective of this study was to investigate the influence of a high-sodium, high-protein diet on bone metabolism in postmenopausal women (aged 49-60 y) stratified by hormone replacement therapy (HRT) use. In a crossover trial, 18 women (n = 8 HRT users (+HRT) and n = 10 nonusers (-HRT)) were randomly assigned to a diet high in protein (90 g/day) and sodium (180 mmol/day) (calciuric diet) or a diet moderate in protein (70 g/day) and low in sodium (65 mmol/day) for 4 weeks followed by crossover to alternative dietary regimen for a further 4 weeks. The calciuric diet significantly (P < 0.05) increased urinary sodium, calcium and nitrogen in both groups. While the calciuric diet increased urinary N-telopeptide crosslinks of collagen (by approximately 25%, P = 0.003) in the -HRT group, it had no effect in the +HRT group. It appears that postmenopausal HRT use attenuates the increase in a marker of bone resorption associated with a calciuric diet.