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Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction
Background: We investigated the safety and efficacy of GCSF therapy in a porcine model of ischemia–reperfusion with left ventricle ejection fraction of
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| Published in: | Cytokine (Philadelphia, Pa.) Pa.), 2010-09, Vol.51 (3), p.278-285 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 285 |
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| container_title | Cytokine (Philadelphia, Pa.) |
| container_volume | 51 |
| creator | Angeli, Franca S. Smith, Charles Amabile, Nicolas Shapiro, Mia Bartlett, Lauren Virmani, Renu Chatterjee, Kanu Boyle, Andrew Grossman, William Yeghiazarians, Yerem |
| description | Background: We investigated the safety and efficacy of GCSF therapy in a porcine model of ischemia–reperfusion with left ventricle ejection fraction of |
| doi_str_mv | 10.1016/j.cyto.2010.06.003 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754895363</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1043466610001535</els_id><sourcerecordid>754895363</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-9c5b083936b7219d0dc20fe88b822ebaf80e06e00e36675994b196d7522b3d5e3</originalsourceid><addsrcrecordid>eNqFkLFOwzAQhi0EoqXwAgwoG1PCxU6cWGJBFRQkJBYYmCzHuYCrJC52QtW3x6WFEaa7-_XdP3yEnKeQpJDyq2WiN4NNKIQAeALADsg0BcFjAMoOt3vG4oxzPiEn3i8BQLCiOCYTChxELoopeV041Y-tDU0YadvafhP5wXRjqwbTv0WN0oN1kemjbmO1crVRbbga5fRgbB-tzfAetXYd4RJ3SePU93JKjhrVejzbzxl5ubt9nt_Hj0-Lh_nNY6xZWQyx0HkFJROMVwVNRQ21ptBgWVYlpVippgQEjgDIOC9yIbIqFbwuckorVufIZuRy17ty9mNEP8jOeI1tq3q0o5dFnpUiZ5z9TwaQiZzzQNIdqZ313mEjV850ym1kCnLrXi7l1r3cupfAZXAfni729WPVYf378iM7ANc7AIOOT4NOem2w11gbF-TJ2pq_-r8AqOaWSQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>748939566</pqid></control><display><type>article</type><title>Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction</title><source>ScienceDirect Journals</source><creator>Angeli, Franca S. ; Smith, Charles ; Amabile, Nicolas ; Shapiro, Mia ; Bartlett, Lauren ; Virmani, Renu ; Chatterjee, Kanu ; Boyle, Andrew ; Grossman, William ; Yeghiazarians, Yerem</creator><creatorcontrib>Angeli, Franca S. ; Smith, Charles ; Amabile, Nicolas ; Shapiro, Mia ; Bartlett, Lauren ; Virmani, Renu ; Chatterjee, Kanu ; Boyle, Andrew ; Grossman, William ; Yeghiazarians, Yerem</creatorcontrib><description>Background: We investigated the safety and efficacy of GCSF therapy in a porcine model of ischemia–reperfusion with left ventricle ejection fraction of <45% using a clinically relevant dosing and timing regimen.
Methods: MI was induced in pigs by a 90
min balloon occlusion of the left anterior descending coronary artery. Sixteen animals were randomized to either GCSF (IV bolus of 10
μg/kg at time of reperfusion, followed by SC injections of 5
μg/kg days 5–9 post-MI) or saline (control group). Inflammatory markers, bone marrow cell mobilization and LV function (echocardiography and pressure–volume measurements) were assessed at baseline, 1 and 6
weeks post-MI. Histopathology was performed 6
weeks post-MI.
Results: GCSF therapy was associated with a significant increase in white blood cell counts. At week 6, GCSF therapy resulted in less deterioration of LVEF compared to control (38
±
2% vs. 33
±
2%,
p
<
0.02) and improved wall motion score index (
p
<
0.05). Histopathology revealed increased vascular density (
p
<
0.05) and a trend toward increased areas of viable myocardium compared to control (
p
=
0.058).
Conclusion: GCSF therapy prevents further deterioration of LV function in a porcine model of MI with lower EF (<45%). These results support future clinical trials with GCSF in selected patients with larger MI.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2010.06.003</identifier><identifier>PMID: 20609597</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Bone Marrow Cells - cytology ; Bone Marrow Cells - drug effects ; Cardiac remodeling ; Catheterization ; Cell Movement - drug effects ; Cicatrix - pathology ; Cytokine ; Fibrosis ; Granulocyte colony stimulating factor ; Granulocyte Colony-Stimulating Factor - pharmacology ; Granulocyte Colony-Stimulating Factor - therapeutic use ; Myocardial infarction ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - drug therapy ; Myocardial Infarction - pathology ; Myocardial Infarction - physiopathology ; Neovascularization, Physiologic - drug effects ; Stroke Volume - drug effects ; Stroke Volume - physiology ; Sus scrofa ; Time Factors ; Ultrasonography</subject><ispartof>Cytokine (Philadelphia, Pa.), 2010-09, Vol.51 (3), p.278-285</ispartof><rights>2010 Elsevier Ltd</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-9c5b083936b7219d0dc20fe88b822ebaf80e06e00e36675994b196d7522b3d5e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20609597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Angeli, Franca S.</creatorcontrib><creatorcontrib>Smith, Charles</creatorcontrib><creatorcontrib>Amabile, Nicolas</creatorcontrib><creatorcontrib>Shapiro, Mia</creatorcontrib><creatorcontrib>Bartlett, Lauren</creatorcontrib><creatorcontrib>Virmani, Renu</creatorcontrib><creatorcontrib>Chatterjee, Kanu</creatorcontrib><creatorcontrib>Boyle, Andrew</creatorcontrib><creatorcontrib>Grossman, William</creatorcontrib><creatorcontrib>Yeghiazarians, Yerem</creatorcontrib><title>Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>Background: We investigated the safety and efficacy of GCSF therapy in a porcine model of ischemia–reperfusion with left ventricle ejection fraction of <45% using a clinically relevant dosing and timing regimen.
Methods: MI was induced in pigs by a 90
min balloon occlusion of the left anterior descending coronary artery. Sixteen animals were randomized to either GCSF (IV bolus of 10
μg/kg at time of reperfusion, followed by SC injections of 5
μg/kg days 5–9 post-MI) or saline (control group). Inflammatory markers, bone marrow cell mobilization and LV function (echocardiography and pressure–volume measurements) were assessed at baseline, 1 and 6
weeks post-MI. Histopathology was performed 6
weeks post-MI.
Results: GCSF therapy was associated with a significant increase in white blood cell counts. At week 6, GCSF therapy resulted in less deterioration of LVEF compared to control (38
±
2% vs. 33
±
2%,
p
<
0.02) and improved wall motion score index (
p
<
0.05). Histopathology revealed increased vascular density (
p
<
0.05) and a trend toward increased areas of viable myocardium compared to control (
p
=
0.058).
Conclusion: GCSF therapy prevents further deterioration of LV function in a porcine model of MI with lower EF (<45%). These results support future clinical trials with GCSF in selected patients with larger MI.</description><subject>Animals</subject><subject>Bone Marrow Cells - cytology</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Cardiac remodeling</subject><subject>Catheterization</subject><subject>Cell Movement - drug effects</subject><subject>Cicatrix - pathology</subject><subject>Cytokine</subject><subject>Fibrosis</subject><subject>Granulocyte colony stimulating factor</subject><subject>Granulocyte Colony-Stimulating Factor - pharmacology</subject><subject>Granulocyte Colony-Stimulating Factor - therapeutic use</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Stroke Volume - drug effects</subject><subject>Stroke Volume - physiology</subject><subject>Sus scrofa</subject><subject>Time Factors</subject><subject>Ultrasonography</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkLFOwzAQhi0EoqXwAgwoG1PCxU6cWGJBFRQkJBYYmCzHuYCrJC52QtW3x6WFEaa7-_XdP3yEnKeQpJDyq2WiN4NNKIQAeALADsg0BcFjAMoOt3vG4oxzPiEn3i8BQLCiOCYTChxELoopeV041Y-tDU0YadvafhP5wXRjqwbTv0WN0oN1kemjbmO1crVRbbga5fRgbB-tzfAetXYd4RJ3SePU93JKjhrVejzbzxl5ubt9nt_Hj0-Lh_nNY6xZWQyx0HkFJROMVwVNRQ21ptBgWVYlpVippgQEjgDIOC9yIbIqFbwuckorVufIZuRy17ty9mNEP8jOeI1tq3q0o5dFnpUiZ5z9TwaQiZzzQNIdqZ313mEjV850ym1kCnLrXi7l1r3cupfAZXAfni729WPVYf378iM7ANc7AIOOT4NOem2w11gbF-TJ2pq_-r8AqOaWSQ</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Angeli, Franca S.</creator><creator>Smith, Charles</creator><creator>Amabile, Nicolas</creator><creator>Shapiro, Mia</creator><creator>Bartlett, Lauren</creator><creator>Virmani, Renu</creator><creator>Chatterjee, Kanu</creator><creator>Boyle, Andrew</creator><creator>Grossman, William</creator><creator>Yeghiazarians, Yerem</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100901</creationdate><title>Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction</title><author>Angeli, Franca S. ; Smith, Charles ; Amabile, Nicolas ; Shapiro, Mia ; Bartlett, Lauren ; Virmani, Renu ; Chatterjee, Kanu ; Boyle, Andrew ; Grossman, William ; Yeghiazarians, Yerem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-9c5b083936b7219d0dc20fe88b822ebaf80e06e00e36675994b196d7522b3d5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Bone Marrow Cells - cytology</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Cardiac remodeling</topic><topic>Catheterization</topic><topic>Cell Movement - drug effects</topic><topic>Cicatrix - pathology</topic><topic>Cytokine</topic><topic>Fibrosis</topic><topic>Granulocyte colony stimulating factor</topic><topic>Granulocyte Colony-Stimulating Factor - pharmacology</topic><topic>Granulocyte Colony-Stimulating Factor - therapeutic use</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Stroke Volume - drug effects</topic><topic>Stroke Volume - physiology</topic><topic>Sus scrofa</topic><topic>Time Factors</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Angeli, Franca S.</creatorcontrib><creatorcontrib>Smith, Charles</creatorcontrib><creatorcontrib>Amabile, Nicolas</creatorcontrib><creatorcontrib>Shapiro, Mia</creatorcontrib><creatorcontrib>Bartlett, Lauren</creatorcontrib><creatorcontrib>Virmani, Renu</creatorcontrib><creatorcontrib>Chatterjee, Kanu</creatorcontrib><creatorcontrib>Boyle, Andrew</creatorcontrib><creatorcontrib>Grossman, William</creatorcontrib><creatorcontrib>Yeghiazarians, Yerem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Angeli, Franca S.</au><au>Smith, Charles</au><au>Amabile, Nicolas</au><au>Shapiro, Mia</au><au>Bartlett, Lauren</au><au>Virmani, Renu</au><au>Chatterjee, Kanu</au><au>Boyle, Andrew</au><au>Grossman, William</au><au>Yeghiazarians, Yerem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>51</volume><issue>3</issue><spage>278</spage><epage>285</epage><pages>278-285</pages><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>Background: We investigated the safety and efficacy of GCSF therapy in a porcine model of ischemia–reperfusion with left ventricle ejection fraction of <45% using a clinically relevant dosing and timing regimen.
Methods: MI was induced in pigs by a 90
min balloon occlusion of the left anterior descending coronary artery. Sixteen animals were randomized to either GCSF (IV bolus of 10
μg/kg at time of reperfusion, followed by SC injections of 5
μg/kg days 5–9 post-MI) or saline (control group). Inflammatory markers, bone marrow cell mobilization and LV function (echocardiography and pressure–volume measurements) were assessed at baseline, 1 and 6
weeks post-MI. Histopathology was performed 6
weeks post-MI.
Results: GCSF therapy was associated with a significant increase in white blood cell counts. At week 6, GCSF therapy resulted in less deterioration of LVEF compared to control (38
±
2% vs. 33
±
2%,
p
<
0.02) and improved wall motion score index (
p
<
0.05). Histopathology revealed increased vascular density (
p
<
0.05) and a trend toward increased areas of viable myocardium compared to control (
p
=
0.058).
Conclusion: GCSF therapy prevents further deterioration of LV function in a porcine model of MI with lower EF (<45%). These results support future clinical trials with GCSF in selected patients with larger MI.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>20609597</pmid><doi>10.1016/j.cyto.2010.06.003</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Cardiac remodeling Catheterization Cell Movement - drug effects Cicatrix - pathology Cytokine Fibrosis Granulocyte colony stimulating factor Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte Colony-Stimulating Factor - therapeutic use Myocardial infarction Myocardial Infarction - diagnostic imaging Myocardial Infarction - drug therapy Myocardial Infarction - pathology Myocardial Infarction - physiopathology Neovascularization, Physiologic - drug effects Stroke Volume - drug effects Stroke Volume - physiology Sus scrofa Time Factors Ultrasonography |
| title | Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction |
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