Tissue morphogenesis coupled with cell shape changes

When different tissues successively emerge during development, they need to be morphologically segregated from each other. Morphological segregation of tissues is often accompanied by robust changes in cell shape, and these two events are precisely coordinated. We overview recent progress in underst...

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Bibliographic Details
Published in:Current opinion in genetics & development 2010-08, Vol.20 (4), p.443-447
Main Authors: Watanabe, Tadayoshi, Takahashi, Yoshiko
Format: Article
Language:English
Subjects:
cdc42 GTP-Binding Protein - metabolism
cdc42 GTP-Binding Protein - physiology
Cdc42 protein
Cell Communication
Cell Shape
Ephrins - metabolism
Ephrins - physiology
Epithelial Cells - cytology
Epithelial Cells - metabolism
Fibronectins - biosynthesis
Medical Education
Mesoderm - cytology
Mesoderm - embryology
Mesoderm - metabolism
Morphogenesis - genetics
Neoplasms - metabolism
Neoplasms - pathology
Signal Transduction
Somites - cytology
Somites - embryology
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Summary:When different tissues successively emerge during development, they need to be morphologically segregated from each other. Morphological segregation of tissues is often accompanied by robust changes in cell shape, and these two events are precisely coordinated. We overview recent progress in understanding how such coordination is regulated at the cellular and molecular levels using vertebrate somitogenesis as a unique model. In the formation of the somitic gap and its concomitant cell epithelialization, Ephrin-Eph intercellular signals play a central role, with Ephrin transducing intracellular signals via suppression of Cdc42. These signals lead to the activation of integrin where the segment border of somites forms, which in turn induces the assembly of fibronectin, the final player for the coordination. Intimate coupling of tissue-shape and cell-shape changes is also relevant to tumor suppression.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2010.05.004