Intake of purple sweet potato beverage affects on serum hepatic biomarker levels of healthy adult men with borderline hepatitis

• Published in: European journal of clinical nutrition 2008-01, Vol.62 (1), p.60-67
• Main Authors: Suda, I, Ishikawa, F, Hatakeyama, M, Miyawaki, M, Kudo, T, Hirano, K, Ito, A, Yamakawa, O, Horiuchi, S
• Format: Article
• Language: English
• Subjects: Adult; adults; alanine transaminase; Alanine Transaminase - metabolism; alcoholic beverages; Anthocyanin; anthocyanins; Anthocyanins - therapeutic use; Aspartate Aminotransferases - metabolism; aspertate aminotransferase; Beverages; Biological and medical sciences; Biological markers; Biomarkers - blood; blood serum; Chemical properties; Clinical Nutrition; Diagnosis; Diet therapy; Double-Blind Method; Epidemiology; Evaluation; gamma-glutamyltransferase; gamma-Glutamyltransferase - metabolism; Gastroenterology. Liver. Pancreas. Abdomen; Health aspects; hematologic tests; Hepatitis; Hepatitis - blood; Hepatitis - drug therapy; Humans; Ingestion; Internal Medicine; Ipomoea batatas; Ipomoea batatas - chemistry; liver; Liver - drug effects; Liver - enzymology; liver function; Liver Function Tests; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Medicine; Medicine & Public Health; Men; Metabolic Diseases; Middle Aged; nutrient intake; Nutrition; Nutritional aspects; nutritional intervention; original-article; Other diseases. Semiology; Polyphenols; Potatoes; Public Health; Solanum tuberosum; Sweet potatoes; Variance analysis; vegetable juices; Vegetables
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/sj.ejcn.1602674

Objective: To examine the effect of purple sweet potato (PSP) beverage rich in acylated anthocyanins on serum hepatic biomarkers in healthy Japanese men. Design: A randomized, double-blind, placebo-controlled, parallel study. Setting: Kumamoto in Japan. Subjects: Healthy adult men (30-60 years) with borderline hepatitis who had one or more of serum γ-glutamyl transferase (GGT), aspertate aminotransferase (AST) and alanine aminotransferase (ALT) levels over normal ranges, and who were negative for hepatitis virus were openly recruited by an advertisement. Of the 48 persons enrolled, 38 (mean age 43.0 years (30-54 years)) completed the study. Methods: The subjects were randomly assigned to the PSP group and the placebo group. During the 8-week intervention, the subjects in the PSP group consumed two bottles of the PSP beverage with acylated anthocyanins (200.3 mg anthocyanins per 125 ml per bottle) per day, and the subjects in the placebo group, two bottles of a placebo beverage (1.7 mg anthocyanins per 125 ml per bottle). All of the data measured were analyzed by two-way repeated measures analysis of variance (ANOVA) with groups and times. The data of the hepatic markers were analyzed using the Dunnett multiple comparison among the time points and t-test between groups at the same time point. Two-sided P