Cellular interactions of biodegradable nanorod arrays prepared by nondestructive extraction from nanoporous alumina

Biodegradable extracellular matrices (ECMs) consisting of mechanically stable arrays of aligned poly(lactide) nanorods (nanorod diameter - 200 run; lattice constant - 500 nm) with areas up to 9 cm super(2) were prepared by nondestructive extraction from recyclable self-ordered nanoporous alumina har...

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Bibliographic Details
Published in:Journal of materials chemistry 2010-01, Vol.20 (16), p.3171-3177
Main Authors: Grimm, Silko, Martín, Jaime, Rodriguez, Gema, Fernández-Gutierrez, Mar, Mathwig, Klaus, Wehrspohn, Ralf B., Gösele, Ulrich, San Roman, Julio, Mijangos, Carmen, Steinhart, Martin
Format: Article
Language:English
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Summary:Biodegradable extracellular matrices (ECMs) consisting of mechanically stable arrays of aligned poly(lactide) nanorods (nanorod diameter - 200 run; lattice constant - 500 nm) with areas up to 9 cm super(2) were prepared by nondestructive extraction from recyclable self-ordered nanoporous alumina hard templates. Fibroblasts formed dense tissue layers on the heparin/gelatin activated nanorod arrays, showed excellent adhesion and exhibited a highly elongated morphology such as in natural tissue. The synthetic approach reported here combining advantages of top-down lithography (well-defined topography) and self-assembly (low costs, high throughput, feature size in the 100 nm range) may yield ECMs for biomedical applications. Remarkably, on microrod arrays with four times larger feature sizes the fibroblasts were significantly less elongated and their proliferation was strongly reduced.
ISSN:0959-9428
1364-5501
DOI:10.1039/b926432a