Human Papilloma Virus Type and Recurrence Rate After Surgical Clearance of Anal Condylomata Acuminata

• Published in: Sexually transmitted diseases 2009-09, Vol.36 (9), p.536-540
• Main Authors: D'Ambrogio, Aris, Yerly, Stéphane, Sahli, Roland, Bouzourene, Hanifa, Demartines, Nicolas, Cotton, Michael, Givel, Jean-Claude
• Format: Article
• Language: English
• Subjects: Adult; Anal Canal - virology; Biological and medical sciences; Condylomata Acuminata - epidemiology; Condylomata Acuminata - prevention & control; Condylomata Acuminata - surgery; Condylomata Acuminata - virology; Epidemiology. Vaccinations; Female; General aspects; Genotype; Hospitals, University; Human immunodeficiency virus; Human infectious diseases. Experimental studies and models; Human papillomavirus; Human papillomavirus 11 - classification; Human papillomavirus 11 - genetics; Human papillomavirus 11 - isolation & purification; Human papillomavirus 6 - classification; Human papillomavirus 6 - genetics; Human papillomavirus 6 - isolation & purification; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Monte Carlo Method; Papillomaviridae - classification; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - epidemiology; Papillomavirus Infections - prevention & control; Papillomavirus Infections - surgery; Papillomavirus Infections - virology; Recurrence; Surveys and Questionnaires; Switzerland - epidemiology; Viral diseases; Viral diseases of the genital and urinary system
• ISSN: 0148-5717; 1537-4521
• DOI: 10.1097/OLQ.0b013e3181a866a3

Background: Anal condylomata acuminata are caused by human papilloma virus (HPV) infection which is transmitted by close physical and sexual contact. The result of surgical treatment of ACA has an overall success rate of 71% to 93%, with a recurrence rate between 4% and 29%. The aim of this study was to assess a possible association between HPV type and recurrence after surgical treatment. Methods: We performed a retrospective analysis of 140 consecutive patients who underwent surgery for from January 1990 to December 2005 at our tertiary University Hospital. We confirmed by histopathological analysis and determined the HPV typing using the polymerase chain reaction. Patients gave consent for HPV testing and completed a questionnaire. We looked at the association of ACA HPV typing, and HIV disease. We used X², the Monte Carlo simulation, and Wilcoxon tests for statistical analysis. Results: Among the 140 patients (123 M/17 F), HPV 6 and 11 were the most frequently encountered viruses (51 % and 28%, respectively). Recurrence occurred in 35 (25%) patients. HPV 11 was present in 19 (41%) of these recurrences, which is statistically significant, when compared with other HPVs. There was no significant difference between recurrence rates in the 33 (24%) HIV-positive and the HIVnegative patients. Conclusions: HPV 11 is associated with higher recurrence rate of This makes routine clinical HPV typing questionable. Follow-up is required to identify recurrence and to treat it early, especially if HPV 11 has been identified.