Inhibition of Prostaglandin Synthesizing Enzymes by Haptoglobin and Plasma of Rats with Inflammation

Administration of carrageenin or adjuvant to rats to induce inflammation produced increases in the plasma haptoglobin level. Simultaneously, there was an increase in the activity of the plasma inhibitor of prostaglandin E2 synthesis. Partially purified haptoglobin inhibited the microsomal over-all c...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of pharmacology 1980-12, Vol.30 (6), p.899-904
Main Authors: Komoriya, Keiji, Hoshina, Kenji, Ohtsu, Akira, Saito, Noriyuki, Kurozumi, Seizi, Naruchi, Tatsuyuki, Hashimoto, Yoshinobu, Mizuno, Keiko, Yamamoto, Shozo
Format: Article
Language:English
Subjects:
Animals
Arachidonic Acids - metabolism
Cyclooxygenase Inhibitors
Haptoglobins - physiology
Inflammation - blood
Male
Peroxidases - antagonists & inhibitors
Prostaglandin Endoperoxides - antagonists & inhibitors
Prostaglandins E - biosynthesis
Rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Administration of carrageenin or adjuvant to rats to induce inflammation produced increases in the plasma haptoglobin level. Simultaneously, there was an increase in the activity of the plasma inhibitor of prostaglandin E2 synthesis. Partially purified haptoglobin inhibited the microsomal over-all conversion of arachidonic acid to prostaglandin E2. The addition of the haptoglobin inhibited two heme-dependent reactions catalyzed by a purified enzyme of seminal vesicle microsome, i.e., the prostaglandin G2 synthesis from arachidonic acid and the conversion of prostaglandin G2 to H2. However, the plasma inhibitory activity was accounted for only partially by the haptoglobin contained in the plasma from treated rats.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)52948-1