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Hypoxic contraction of isolated rat pulmonary artery

The effects of hypoxia in precontracted rat pulmonary artery rings with and without endothelium was studied. Hypoxia (30 mmHg) produced a contraction (hypoxic pulmonary vasoconstriction, HPV). Removal of endothelium abolished the HPV. The HPV was reproducible. The amplitude of HPV was similar to art...

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Published in:	Journal of smooth muscle research 1995-12, Vol.31 (6), p.471-475
Main Authors:	Lee, Y H, Lee, H Y, Lee, E Y, Kang, B S
Format:	Article
Language:	English
Subjects:	Animals Caffeine - pharmacology Cell Hypoxia Cyclooxygenase Inhibitors - pharmacology Endothelium, Vascular - physiology In Vitro Techniques Indomethacin - pharmacology Nifedipine - pharmacology Nitric Oxide - biosynthesis Oxygen - metabolism Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pulmonary Artery - physiology Rats Vasoconstriction - drug effects Vasodilator Agents - pharmacology
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container_issue	6
container_start_page	471
container_title	Journal of smooth muscle research
container_volume	31
creator	Lee, Y H Lee, H Y Lee, E Y Kang, B S
description	The effects of hypoxia in precontracted rat pulmonary artery rings with and without endothelium was studied. Hypoxia (30 mmHg) produced a contraction (hypoxic pulmonary vasoconstriction, HPV). Removal of endothelium abolished the HPV. The HPV was reproducible. The amplitude of HPV was similar to arteries equilibrated with 100% O2 and room air. L-NNA markedly inhibited the HPV whereas indomethacin was ineffective. HPV was inhibited by caffeine, but not inhibited by nifedipine. It would be concluded that HPV in isolated rat pulmonary arteries is dependent on the endothelium and the mechanisms involved may be inhibition of basal NO production.
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Hypoxia (30 mmHg) produced a contraction (hypoxic pulmonary vasoconstriction, HPV). Removal of endothelium abolished the HPV. The HPV was reproducible. The amplitude of HPV was similar to arteries equilibrated with 100% O2 and room air. L-NNA markedly inhibited the HPV whereas indomethacin was ineffective. HPV was inhibited by caffeine, but not inhibited by nifedipine. 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Hypoxia (30 mmHg) produced a contraction (hypoxic pulmonary vasoconstriction, HPV). Removal of endothelium abolished the HPV. The HPV was reproducible. The amplitude of HPV was similar to arteries equilibrated with 100% O2 and room air. L-NNA markedly inhibited the HPV whereas indomethacin was ineffective. HPV was inhibited by caffeine, but not inhibited by nifedipine. It would be concluded that HPV in isolated rat pulmonary arteries is dependent on the endothelium and the mechanisms involved may be inhibition of basal NO production.</description><subject>Animals</subject><subject>Caffeine - pharmacology</subject><subject>Cell Hypoxia</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Endothelium, Vascular - physiology</subject><subject>In Vitro Techniques</subject><subject>Indomethacin - pharmacology</subject><subject>Nifedipine - pharmacology</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Oxygen - metabolism</subject><subject>Pulmonary Artery - drug effects</subject><subject>Pulmonary Artery - metabolism</subject><subject>Pulmonary Artery - physiology</subject><subject>Rats</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0916-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNotj81KxDAYRbNQxnH0EYSs3BXyM19-ljKoIwzMRtclTb5ApW1qkoJ9ewec1dkcDvfekC2zXDVGS31H7kv5ZkwYsHZDNsYobbXakv1xndNv76lPU83O1z5NNEXalzS4ioFmV-m8DGOaXF6pyxXz-kBuoxsKPl65I19vr5-HY3M6v38cXk7NzAWvjZLBRJQGFRpwneVR2MBRY-iYArH3BgIg49CBjZ513jAQEkXUGhRyKXfk-b875_SzYKnt2BePw-AmTEtpNQADI_hFfLqKSzdiaOfcj5e57fWm_ANPaE2H</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>Lee, Y H</creator><creator>Lee, H Y</creator><creator>Lee, E Y</creator><creator>Kang, B S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199512</creationdate><title>Hypoxic contraction of isolated rat pulmonary artery</title><author>Lee, Y H ; Lee, H Y ; Lee, E Y ; Kang, B S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-63d8fe38e6e85ab91f29d1e7edb06524c85d5e015b59fc0bc80523e2f7756e133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Caffeine - pharmacology</topic><topic>Cell Hypoxia</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>Endothelium, Vascular - physiology</topic><topic>In Vitro Techniques</topic><topic>Indomethacin - pharmacology</topic><topic>Nifedipine - pharmacology</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Oxygen - metabolism</topic><topic>Pulmonary Artery - drug effects</topic><topic>Pulmonary Artery - metabolism</topic><topic>Pulmonary Artery - physiology</topic><topic>Rats</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Y H</creatorcontrib><creatorcontrib>Lee, H Y</creatorcontrib><creatorcontrib>Lee, E Y</creatorcontrib><creatorcontrib>Kang, B S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of smooth muscle research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Y H</au><au>Lee, H Y</au><au>Lee, E Y</au><au>Kang, B S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxic contraction of isolated rat pulmonary artery</atitle><jtitle>Journal of smooth muscle research</jtitle><addtitle>J Smooth Muscle Res</addtitle><date>1995-12</date><risdate>1995</risdate><volume>31</volume><issue>6</issue><spage>471</spage><epage>475</epage><pages>471-475</pages><issn>0916-8737</issn><abstract>The effects of hypoxia in precontracted rat pulmonary artery rings with and without endothelium was studied. 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source	J-STAGE (Japan Science & Tech Info) Free
subjects	Animals Caffeine - pharmacology Cell Hypoxia Cyclooxygenase Inhibitors - pharmacology Endothelium, Vascular - physiology In Vitro Techniques Indomethacin - pharmacology Nifedipine - pharmacology Nitric Oxide - biosynthesis Oxygen - metabolism Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pulmonary Artery - physiology Rats Vasoconstriction - drug effects Vasodilator Agents - pharmacology
title	Hypoxic contraction of isolated rat pulmonary artery
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