Nucleotide sequences at host–proviral junctions for mouse mammary tumour virus

Proviruses cloned from rat cells infected with mouse mammary tumour virus, a B-type retrovirus regulated by glucocorticoid hormones, show the structural features of transposable elements: short inverted repeats conclude long direct repeats at the ends of viral DNA, and short sequences of cellular DN...

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Bibliographic Details
Published in:Nature (London) 1981-01, Vol.289 (5795), p.253-258
Main Authors: Majors, John E., Varmus, Harold E.
Format: Article
Language:English
Subjects:
Animals
Bacteriophage lambda
Base Sequence
Cell Transformation, Viral
Cells, Cultured
Cloning, Molecular - methods
DNA, Neoplasm - genetics
DNA, Viral - genetics
Female
Genetic Linkage
Humanities and Social Sciences
Mammary Tumor Virus, Mouse - genetics
Mice
multidisciplinary
Plasmids
Rats
Recombination, Genetic
Science
Science (multidisciplinary)
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Description
Summary:Proviruses cloned from rat cells infected with mouse mammary tumour virus, a B-type retrovirus regulated by glucocorticoid hormones, show the structural features of transposable elements: short inverted repeats conclude long direct repeats at the ends of viral DNA, and short sequences of cellular DNA are duplicated during integration and flank each provirus. The integrative mechanism joins a precise site in viral DNA to non-homologous sites in host DNA.
ISSN:0028-0836
1476-4687
DOI:10.1038/289253a0