Tuberous sclerosis complex: linking cancer to metabolism

The TSC1/TSC2 tumor-suppressor complex regulates cell growth via controlling the mTOR (mammalian target of rapamycin) signaling pathway, which contributes to several disease processes, including cancer and diabetes. Abnormal activation of mTOR uncouples anabolic cell growth processes such as protein...

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Bibliographic Details
Published in:Trends in molecular medicine 2010-07, Vol.16 (7), p.329-335
Main Authors: Mieulet, Virginie, Lamb, Richard F
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation
Feedback, Physiological
Humans
Mechanistic Target of Rapamycin Complex 1
Multiprotein Complexes
Neoplasms - metabolism
Neoplasms - pathology
Pathology
Proteins
Signal Transduction
TOR Serine-Threonine Kinases
Transcription Factors - metabolism
Tumor Suppressor Proteins - metabolism
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Summary:The TSC1/TSC2 tumor-suppressor complex regulates cell growth via controlling the mTOR (mammalian target of rapamycin) signaling pathway, which contributes to several disease processes, including cancer and diabetes. Abnormal activation of mTOR uncouples anabolic cell growth processes such as protein and lipid synthesis from external growth factor or nutrient cues. However, abnormal activation of mTOR upon loss of TSC1/TSC2 complex function is now known to lead to compensatory mechanisms that restrict the development of malignant tumors. The rare occurrence of complete loss of TSC1/TSC2 function in human tumors suggests that retaining growth suppressor activity might be beneficial during tumour evolution, perhaps by promoting survival when cells grow in a nutrient-limited environment.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2010.05.001