Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes

A transcriptome analysis compared gene expression in human bone biopsy samples taken from lumbar spine and iliac crest, sites that experience high and low levels of mechanical stress, respectively. The analysis revealed that the zinc finger protein of cerebellum (Zic) family member transcription fac...

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Bibliographic Details
Published in:The FASEB journal 2010-08, Vol.24 (8), p.2893-2903
Main Authors: Kalogeropoulos, Michail, Varanasi, Satya S, Olstad, Ole K, Sanderson, Paul, Gautvik, Vigdis T, Reppe, Sjur, Francis, Roger M, Gautvik, Kaare M, Birch, Mark A, Datta, Harish K
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - metabolism
Cell Line
Cilia
fluid flow
Gene Expression Profiling
Kruppel-Like Transcription Factors - genetics
Kruppel-Like Transcription Factors - physiology
mechanical stress
mechanosensors
Mechanotransduction, Cellular
Mice
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - physiology
Osteocytes - metabolism
Rats
shear stress
Stress, Mechanical
Transcription Factors - physiology
Zinc Finger Protein GLI1
Zinc Finger Protein Gli3
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Summary:A transcriptome analysis compared gene expression in human bone biopsy samples taken from lumbar spine and iliac crest, sites that experience high and low levels of mechanical stress, respectively. The analysis revealed that the zinc finger protein of cerebellum (Zic) family member transcription factor Zic1 was the most up-regulated gene in the lumbar spine (202-fold; P
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.09-148908