Dandy-Walker Like Malformation in a Fischer-344 Rat

A spontaneous cerebellar malformation was found in a 32-day-old male Fischer 344 rat. The cerebellar malformation was composed of a vermis defect and markedly dilated fourth ventricle. The cerebellar hemispheres were separated, with the left hemisphere being smaller than the right one. Degenerative/...

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Bibliographic Details
Published in:Toxicologic pathology 2000-09, Vol.28 (5), p.694-696
Main Authors: Kuwamura, Mitsuru, Morikawa, Takeshi, Yasui, Hisae, Yamate, Jyoji, Kotani, Takao
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Stem - pathology
Cerebellum - pathology
Dandy-Walker Syndrome - pathology
Ependyma - pathology
Hyperplasia - pathology
Inflammation - pathology
Male
Malformations of the nervous system
Medical sciences
Neurology
Rats
Rats, Inbred F344
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Summary:A spontaneous cerebellar malformation was found in a 32-day-old male Fischer 344 rat. The cerebellar malformation was composed of a vermis defect and markedly dilated fourth ventricle. The cerebellar hemispheres were separated, with the left hemisphere being smaller than the right one. Degenerative/inflammatory lesions consisting of macrophage/lymphocyte infiltration, spheroidal calcium depositions, and astrocytic gliosis were seen adjacent to the cerebral aqueduct. Abnormally arranged hyperplastic ependymal cells were observed beneath the fourth ventricle in the medulla oblongata. The gross findings of the present case resemble those of the human Dandy-Walker malformation. While a precise mechanism remains to be elucidated, degenerative/inflammatory lesions in the present rat may be involved in the pathogenesis of this malformation.
ISSN:0192-6233
1533-1601
DOI:10.1177/019262330002800509