Viruses, chemotherapy and immunity

An increasing number of antiviral agents are presently in various stages of development and testing, and an increasing number have recently been licensed for use in humans. These drugs have been used extensively to treat viral infections in immunocompromised individuals, and these studies indicate t...

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Bibliographic Details
Published in:Parasitology 1992-01, Vol.105 (S1), p.S85-S92
Main Authors: Koziel, M. J., Walker, B. D.
Format: Article
Language:English
Subjects:
Acyclovir - pharmacology
Acyclovir - therapeutic use
AIDS-Related Opportunistic Infections - drug therapy
AIDS-Related Opportunistic Infections - immunology
AIDS/HIV
antiretroviral agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - immunology
Drug Resistance, Microbial
Ganciclovir - pharmacology
Ganciclovir - therapeutic use
Herpesviridae Infections - drug therapy
Herpesviridae Infections - immunology
HIV Infections - drug therapy
HIV Infections - immunology
HIV-1
Humans
immune response
Immunity, Cellular - drug effects
interferons
Interferons - pharmacology
Interferons - therapeutic use
Major Histocompatibility Complex - drug effects
viral diseases
Virus Diseases - drug therapy
Virus Diseases - immunology
Zidovudine - pharmacology
Zidovudine - therapeutic use
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Summary:An increasing number of antiviral agents are presently in various stages of development and testing, and an increasing number have recently been licensed for use in humans. These drugs have been used extensively to treat viral infections in immunocompromised individuals, and these studies indicate that for many antiviral agents the response to therapy is highly dependent on the integrity of the underlying host immune response. In particular, the response to zidovudine, acyclovir and ganciclovir in persons with HIV-1 infection is highly dependent upon CD4 number, which can be considered a surrogate marker for the state of host immune function in these subjects. Responses to interferons likewise can be shown to depend on the host immune response, with responses due to both direct antiviral effects of this agent as well as immunomodulatory effects mediated through interferon-induced upregulation of HLA molecule expression.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182000075399