Loading…
Viruses, chemotherapy and immunity
An increasing number of antiviral agents are presently in various stages of development and testing, and an increasing number have recently been licensed for use in humans. These drugs have been used extensively to treat viral infections in immunocompromised individuals, and these studies indicate t...
Saved in:
| Published in: | Parasitology 1992-01, Vol.105 (S1), p.S85-S92 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c378t-78491537ffc262fefde526853864061126872c35a36bd14db9a32b4c1573c95c3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c378t-78491537ffc262fefde526853864061126872c35a36bd14db9a32b4c1573c95c3 |
| container_end_page | S92 |
| container_issue | S1 |
| container_start_page | S85 |
| container_title | Parasitology |
| container_volume | 105 |
| creator | Koziel, M. J. Walker, B. D. |
| description | An increasing number of antiviral agents are presently in various stages of development and testing, and an increasing number have recently been licensed for use in humans. These drugs have been used extensively to treat viral infections in immunocompromised individuals, and these studies indicate that for many antiviral agents the response to therapy is highly dependent on the integrity of the underlying host immune response. In particular, the response to zidovudine, acyclovir and ganciclovir in persons with HIV-1 infection is highly dependent upon CD4 number, which can be considered a surrogate marker for the state of host immune function in these subjects. Responses to interferons likewise can be shown to depend on the host immune response, with responses due to both direct antiviral effects of this agent as well as immunomodulatory effects mediated through interferon-induced upregulation of HLA molecule expression. |
| doi_str_mv | 10.1017/S0031182000075399 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75514075</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0031182000075399</cupid><sourcerecordid>75514075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-78491537ffc262fefde526853864061126872c35a36bd14db9a32b4c1573c95c3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo67r6AzwIiwdPVjNJ89GjLLoKBfHbW0jT1I1u2zVpwf33tnTRg-BcZuB5Z3jnRegQ8BlgEOcPGFMASXBXgtEk2UJjiHkSSeCwjcY9jnq-i_ZCeO9UnHIyQiMgkmGgY3T87HwbbDidmoUt62ZhvV6tp7rKp64s28o16320U-hlsAebPkFPV5ePs-sovZ3fzC7SyFAhm0jIOAFGRVEYwklhi9wywiWjkseYA3SzIIYyTXmWQ5xniaYkiw0wQU3CDJ2gk-HuytefrQ2NKl0wdrnUla3boARjEPdvThAMQuPrELwt1Mq7Uvu1Aqz6XNSfXLqdo83xNitt_rsxBNHxaOAuNPbrB2v_obiggik-v1Npei9fRPyqcKenGw-6zLzL36x6r1tfdQH94-Ib0VZ43w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75514075</pqid></control><display><type>article</type><title>Viruses, chemotherapy and immunity</title><source>Cambridge University Press:JISC Collections:Full Collection Digital Archives (STM and HSS) (218 titles)</source><creator>Koziel, M. J. ; Walker, B. D.</creator><creatorcontrib>Koziel, M. J. ; Walker, B. D.</creatorcontrib><description>An increasing number of antiviral agents are presently in various stages of development and testing, and an increasing number have recently been licensed for use in humans. These drugs have been used extensively to treat viral infections in immunocompromised individuals, and these studies indicate that for many antiviral agents the response to therapy is highly dependent on the integrity of the underlying host immune response. In particular, the response to zidovudine, acyclovir and ganciclovir in persons with HIV-1 infection is highly dependent upon CD4 number, which can be considered a surrogate marker for the state of host immune function in these subjects. Responses to interferons likewise can be shown to depend on the host immune response, with responses due to both direct antiviral effects of this agent as well as immunomodulatory effects mediated through interferon-induced upregulation of HLA molecule expression.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S0031182000075399</identifier><identifier>PMID: 1285013</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acyclovir - pharmacology ; Acyclovir - therapeutic use ; AIDS-Related Opportunistic Infections - drug therapy ; AIDS-Related Opportunistic Infections - immunology ; AIDS/HIV ; antiretroviral agents ; Antiviral Agents - pharmacology ; Antiviral Agents - therapeutic use ; Cytomegalovirus Infections - drug therapy ; Cytomegalovirus Infections - immunology ; Drug Resistance, Microbial ; Ganciclovir - pharmacology ; Ganciclovir - therapeutic use ; Herpesviridae Infections - drug therapy ; Herpesviridae Infections - immunology ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV-1 ; Humans ; immune response ; Immunity, Cellular - drug effects ; interferons ; Interferons - pharmacology ; Interferons - therapeutic use ; Major Histocompatibility Complex - drug effects ; viral diseases ; Virus Diseases - drug therapy ; Virus Diseases - immunology ; Zidovudine - pharmacology ; Zidovudine - therapeutic use</subject><ispartof>Parasitology, 1992-01, Vol.105 (S1), p.S85-S92</ispartof><rights>Copyright © Cambridge University Press 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-78491537ffc262fefde526853864061126872c35a36bd14db9a32b4c1573c95c3</citedby><cites>FETCH-LOGICAL-c378t-78491537ffc262fefde526853864061126872c35a36bd14db9a32b4c1573c95c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0031182000075399/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,55689</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1285013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koziel, M. J.</creatorcontrib><creatorcontrib>Walker, B. D.</creatorcontrib><title>Viruses, chemotherapy and immunity</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>An increasing number of antiviral agents are presently in various stages of development and testing, and an increasing number have recently been licensed for use in humans. These drugs have been used extensively to treat viral infections in immunocompromised individuals, and these studies indicate that for many antiviral agents the response to therapy is highly dependent on the integrity of the underlying host immune response. In particular, the response to zidovudine, acyclovir and ganciclovir in persons with HIV-1 infection is highly dependent upon CD4 number, which can be considered a surrogate marker for the state of host immune function in these subjects. Responses to interferons likewise can be shown to depend on the host immune response, with responses due to both direct antiviral effects of this agent as well as immunomodulatory effects mediated through interferon-induced upregulation of HLA molecule expression.</description><subject>Acyclovir - pharmacology</subject><subject>Acyclovir - therapeutic use</subject><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>AIDS/HIV</subject><subject>antiretroviral agents</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Cytomegalovirus Infections - drug therapy</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Drug Resistance, Microbial</subject><subject>Ganciclovir - pharmacology</subject><subject>Ganciclovir - therapeutic use</subject><subject>Herpesviridae Infections - drug therapy</subject><subject>Herpesviridae Infections - immunology</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV-1</subject><subject>Humans</subject><subject>immune response</subject><subject>Immunity, Cellular - drug effects</subject><subject>interferons</subject><subject>Interferons - pharmacology</subject><subject>Interferons - therapeutic use</subject><subject>Major Histocompatibility Complex - drug effects</subject><subject>viral diseases</subject><subject>Virus Diseases - drug therapy</subject><subject>Virus Diseases - immunology</subject><subject>Zidovudine - pharmacology</subject><subject>Zidovudine - therapeutic use</subject><issn>0031-1820</issn><issn>1469-8161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMo67r6AzwIiwdPVjNJ89GjLLoKBfHbW0jT1I1u2zVpwf33tnTRg-BcZuB5Z3jnRegQ8BlgEOcPGFMASXBXgtEk2UJjiHkSSeCwjcY9jnq-i_ZCeO9UnHIyQiMgkmGgY3T87HwbbDidmoUt62ZhvV6tp7rKp64s28o16320U-hlsAebPkFPV5ePs-sovZ3fzC7SyFAhm0jIOAFGRVEYwklhi9wywiWjkseYA3SzIIYyTXmWQ5xniaYkiw0wQU3CDJ2gk-HuytefrQ2NKl0wdrnUla3boARjEPdvThAMQuPrELwt1Mq7Uvu1Aqz6XNSfXLqdo83xNitt_rsxBNHxaOAuNPbrB2v_obiggik-v1Npei9fRPyqcKenGw-6zLzL36x6r1tfdQH94-Ib0VZ43w</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>Koziel, M. J.</creator><creator>Walker, B. D.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920101</creationdate><title>Viruses, chemotherapy and immunity</title><author>Koziel, M. J. ; Walker, B. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-78491537ffc262fefde526853864061126872c35a36bd14db9a32b4c1573c95c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acyclovir - pharmacology</topic><topic>Acyclovir - therapeutic use</topic><topic>AIDS-Related Opportunistic Infections - drug therapy</topic><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>AIDS/HIV</topic><topic>antiretroviral agents</topic><topic>Antiviral Agents - pharmacology</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Cytomegalovirus Infections - drug therapy</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Drug Resistance, Microbial</topic><topic>Ganciclovir - pharmacology</topic><topic>Ganciclovir - therapeutic use</topic><topic>Herpesviridae Infections - drug therapy</topic><topic>Herpesviridae Infections - immunology</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV-1</topic><topic>Humans</topic><topic>immune response</topic><topic>Immunity, Cellular - drug effects</topic><topic>interferons</topic><topic>Interferons - pharmacology</topic><topic>Interferons - therapeutic use</topic><topic>Major Histocompatibility Complex - drug effects</topic><topic>viral diseases</topic><topic>Virus Diseases - drug therapy</topic><topic>Virus Diseases - immunology</topic><topic>Zidovudine - pharmacology</topic><topic>Zidovudine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koziel, M. J.</creatorcontrib><creatorcontrib>Walker, B. D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koziel, M. J.</au><au>Walker, B. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Viruses, chemotherapy and immunity</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>1992-01-01</date><risdate>1992</risdate><volume>105</volume><issue>S1</issue><spage>S85</spage><epage>S92</epage><pages>S85-S92</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><abstract>An increasing number of antiviral agents are presently in various stages of development and testing, and an increasing number have recently been licensed for use in humans. These drugs have been used extensively to treat viral infections in immunocompromised individuals, and these studies indicate that for many antiviral agents the response to therapy is highly dependent on the integrity of the underlying host immune response. In particular, the response to zidovudine, acyclovir and ganciclovir in persons with HIV-1 infection is highly dependent upon CD4 number, which can be considered a surrogate marker for the state of host immune function in these subjects. Responses to interferons likewise can be shown to depend on the host immune response, with responses due to both direct antiviral effects of this agent as well as immunomodulatory effects mediated through interferon-induced upregulation of HLA molecule expression.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>1285013</pmid><doi>10.1017/S0031182000075399</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-1820 |
| ispartof | Parasitology, 1992-01, Vol.105 (S1), p.S85-S92 |
| issn | 0031-1820 1469-8161 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75514075 |
| source | Cambridge University Press:JISC Collections:Full Collection Digital Archives (STM and HSS) (218 titles) |
| subjects | Acyclovir - pharmacology Acyclovir - therapeutic use AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - immunology AIDS/HIV antiretroviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Cytomegalovirus Infections - drug therapy Cytomegalovirus Infections - immunology Drug Resistance, Microbial Ganciclovir - pharmacology Ganciclovir - therapeutic use Herpesviridae Infections - drug therapy Herpesviridae Infections - immunology HIV Infections - drug therapy HIV Infections - immunology HIV-1 Humans immune response Immunity, Cellular - drug effects interferons Interferons - pharmacology Interferons - therapeutic use Major Histocompatibility Complex - drug effects viral diseases Virus Diseases - drug therapy Virus Diseases - immunology Zidovudine - pharmacology Zidovudine - therapeutic use |
| title | Viruses, chemotherapy and immunity |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T10%3A24%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Viruses,%20chemotherapy%20and%20immunity&rft.jtitle=Parasitology&rft.au=Koziel,%20M.%20J.&rft.date=1992-01-01&rft.volume=105&rft.issue=S1&rft.spage=S85&rft.epage=S92&rft.pages=S85-S92&rft.issn=0031-1820&rft.eissn=1469-8161&rft_id=info:doi/10.1017/S0031182000075399&rft_dat=%3Cproquest_cross%3E75514075%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c378t-78491537ffc262fefde526853864061126872c35a36bd14db9a32b4c1573c95c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=75514075&rft_id=info:pmid/1285013&rft_cupid=10_1017_S0031182000075399&rfr_iscdi=true |