The angioarchitectural factors of the cerebral developmental venous anomaly; can they be the causes of concurrent sporadic cavernous malformation?

• Published in: Neuroradiology 2010-10, Vol.52 (10), p.883-891
• Main Authors: Hong, Yoo Jin, Chung, Tae-Sub, Suh, Sang Hyun, Park, Chul Hwan, Tomar, Geetanjali, Seo, Kwon Duk, Kim, Keung Sik, Park, In Kook
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; Brain; Brain Neoplasms - complications; Brain Neoplasms - pathology; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Cerebral Veins - abnormalities; Cerebral Veins - pathology; Deformation; Diagnostic Neuroradiology; Female; Fundamental and applied biological sciences. Psychology; Hemangioma, Cavernous, Central Nervous System - pathology; Humans; Imaging; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - methods; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Nervous system; Neurology; Neuroradiology; Neurosciences; Neurosurgery; NMR; Nuclear magnetic resonance; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiology; Reproducibility of Results; Sensitivity and Specificity; Vertebrates: nervous system and sense organs
• ISSN: 0028-3940; 1432-1920
• DOI: 10.1007/s00234-009-0640-6

Introduction The aim of this paper was to evaluate the angioarchitectural factors that can induce concurrent cavernous malformation (CM) in the territory of developmental venous anomaly (DVA). Methods From January 2006 to December 2007, 21 patients with 23 CMs in the territory of DVA were retrospectively analyzed (M; F = 12; 9, mean age = 53.3). Gadovist®-enhanced three-dimensional spoiled gradient-echo images on a 3 T magnetic resonance (MR) scanner were used. We investigated the presence of angioarchitectural factors: factor 1, the angulated course of curved medullary or draining vein in the distal portion of CM; factor 2, narrowing of distal draining vein; factor 3, severe medullary venous tortuosity. These were also analyzed for control group of 23 subjects (M; F = 11; 12, mean age = 46). Results Factor 1 was demonstrated in 22 cases (97%) and the CM occurred in a position of 90° or less of an abrupt angulated medullary or draining vein in 15 cases (65%) of the study group. Factor 2 was found in 13 cases (57%) with the diameter reduction of 50% or more in five cases. The mean ratio of diameter reduction was 0.53. Factor 3 was found in 17 cases (74%). Analyzing the independent factors, the p values for factors 1 and 3 were