Red Cell Distribution Width and Risk of Coronary Heart Disease Events

Red cell distribution width (RDW) has emerged as a powerful predictor of all-cause mortality in variety of cardiovascular settings. However, no data are available associating RDW with coronary heart disease (CHD) risk in a healthy and nationally representative multiethnic population. A total of 7,55...

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Bibliographic Details
Published in:The American journal of cardiology 2010-10, Vol.106 (7), p.988-993
Main Authors: Zalawadiya, Sandip K., MD, Veeranna, Vikas, MD, Niraj, Ashutosh, MD, MS, Pradhan, Jyotiranjan, MD, Afonso, Luis, MD
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cells
Coronary Disease - pathology
Coronary heart disease
Erythrocyte Indices
Erythrocytes
Female
Heart
Hemoglobin
Humans
Iron
Male
Medical sciences
Middle Aged
Multivariate analysis
Predictive Value of Tests
Risk Assessment
Risk Factors
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Summary:Red cell distribution width (RDW) has emerged as a powerful predictor of all-cause mortality in variety of cardiovascular settings. However, no data are available associating RDW with coronary heart disease (CHD) risk in a healthy and nationally representative multiethnic population. A total of 7,556 participants of the National Health and Nutrition Examination Surveys 1999 to 2006 (age 41.5 ± 15.8 years, 60% women) were divided into 3 categories according to their 10-year Framingham risk of hard CHD events: 20% (n = 290, high-risk category). Unadjusted and adjusted multivariate logistic regression analyses were performed evaluating RDW as a predictor of CHD risk. Each unit increase (0.1) in RDW posed a statistically significant greater odds of being in the intermediate-risk category (odds ratio −1.35, 95% confidence interval 1.27 to 1.45, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2010.06.006