Pathological aspects of lipid peroxidation

Abstract Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is dis...

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Bibliographic Details
Published in:Free radical research 2010-10, Vol.44 (10), p.1125-1171
Main Authors: Negre-Salvayre, Anne, Auge, Nathalie, Ayala, Victoria, Basaga, Huveyda, Boada, Jordi, Brenke, Rainer, Chapple, Sarah, Cohen, Guy, Feher, Janos, Grune, Tilman, Lengyel, Gabriella, Mann, Giovanni E., Pamplona, Reinald, Poli, Giuseppe, Portero-Otin, Manuel, Riahi, Yael, Salvayre, Robert, Sasson, Shlomo, Serrano, Jose, Shamni, Ofer, Siems, Werner, Siow, Richard C. M., Wiswedel, Ingrid, Zarkovic, Kamelija, Zarkovic, Neven
Format: Article
Language:English
Subjects:
4-hydroxydodecadienal
4-Hydroxynonenal
advanced glycation end-products
Aging - physiology
Alzheimer's disease
amyotrophic lateral sclerosis
Animals
antioxidant enzymes
atherosclerosis
Atherosclerosis - physiopathology
cancer
cell signalling
diabetes
diabetes complications
Diabetes Mellitus - physiopathology
fatty liver
foetal endothelium
glutathione
HELLP syndrome
Human health and pathology
Humans
hyperglycaemia
IUGR
Life Sciences
lipid peroxidation
Lipid Peroxidation - physiology
liver disease
Liver Diseases - physiopathology
lymphoedema
Neoplasms - physiopathology
neurodegenerative diseases
Neurodegenerative Diseases - physiopathology
Nrf2
oxidative homeostasis
Oxidative stress
Oxidative Stress - physiology
oxidized phospholipids
oxysterol
Parkinson's disease
pre-eclampsia
reactive oxygen species
redox equilibrium
redox signaling
renal diseases
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Summary:Abstract Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.
ISSN:1071-5762
1029-2470
DOI:10.3109/10715762.2010.498478