A case of methamphetamine use disorder treated with the antibiotic drug minocycline

Abstract Methamphetamine (METH) use is one of the major public health concerns worldwide. Long-term use of METH induces not only dependence but also psychosis which is associated with METH-induced brain damage, including neuroinflammation produced by activated microglia. We report the case of a fema...

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Bibliographic Details
Published in:General hospital psychiatry 2010-09, Vol.32 (5), p.559.e1-559.e3
Main Authors: Tanibuchi, Yuko, M.D, Shimagami, Minoru, M.D, Fukami, Goro, M.D., Ph.D, Sekine, Yoshimoto, M.D., Ph.D, Iyo, Masaomi, M.D., Ph.D, Hashimoto, Kenji, Ph.D
Format: Article
Language:English
Subjects:
Adolescent
Amphetamine-Related Disorders - complications
Amphetamine-Related Disorders - rehabilitation
Anti-Bacterial Agents - therapeutic use
Antipsychotic Agents - therapeutic use
Brief Psychiatric Rating Scale - statistics & numerical data
Female
Hallucinations - chemically induced
Hallucinations - rehabilitation
Humans
Methamphetamine - toxicity
Minocycline - therapeutic use
Psychiatry
Psychometrics
Psychoses, Substance-Induced - rehabilitation
Substance Abuse, Intravenous - complications
Substance Abuse, Intravenous - rehabilitation
Substance Withdrawal Syndrome - rehabilitation
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Summary:Abstract Methamphetamine (METH) use is one of the major public health concerns worldwide. Long-term use of METH induces not only dependence but also psychosis which is associated with METH-induced brain damage, including neuroinflammation produced by activated microglia. We report the case of a female patient whose psychotic symptoms in METH use disorder were successfully improved by anti-inflammatory drug minocycline therapy. Although the precise mechanism(s) underlying the efficacy of minocycline in METH use disorder are currently unclear, minocycline appears to be a good candidate for future investigation clinical trials for medication development in METH using populations.
ISSN:0163-8343
1873-7714
DOI:10.1016/j.genhosppsych.2009.12.005