Imidazole-Catalyzed Monoacylation of Symmetrical Diamines

An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piper...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2010-10, Vol.12 (19), p.4232-4235
Main Authors: Verma, Sanjeev K, Acharya, B. N, Kaushik, M. P
Format: Article
Language:English
Subjects:
Acylation
Amino Alcohols - chemistry
Catalysis
Diamines - chemistry
Imidazoles - chemistry
Molecular Structure
Stereoisomerism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol101604q