INTERACTIONS OF ADRENERGIC BETA-RECEPTOR BLOCKADE (OXPRENOLOL) AND Pco2 IN THE ANAESTHETIZED DOG: INFLUENCE OF INTRINSIC BETA-SYMPATHOMIMETIC ACTIVITY

Effects of change in Paco2 on systemic and coronary haemodynamics and on coronary sinus blood-gases have been studied in 10 open-chested dogs in which the lungs were ventilated with 0.8% halothane in oxygen, before and after administration of oxprenolol 0.3 mg kg−1 i.v. The hyperdynamic response of...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1981-01, Vol.53 (1), p.19-26
Main Authors: FOËX, P., RYDER, W.A.
Format: Article
Language:English
Subjects:
Anesthesia, General
Animals
Carbon Dioxide - blood
Coronary Circulation - drug effects
Dogs
Halothane
Hemodynamics - drug effects
Oxprenolol - pharmacology
Oxygen - blood
Partial Pressure
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Summary:Effects of change in Paco2 on systemic and coronary haemodynamics and on coronary sinus blood-gases have been studied in 10 open-chested dogs in which the lungs were ventilated with 0.8% halothane in oxygen, before and after administration of oxprenolol 0.3 mg kg−1 i.v. The hyperdynamic response of the circulation to hypercapnia was only marginally reduced after oxprenolol (cardiac output increased by 10% as opposed to 16% before oxprenolol). Before and after oxprenolol, hypocapnia caused large reductions of coronary blood flow (−24% and −20% respectively), while hypercapnia caused large increases of coronary blood flow (+59% and +34% respectively). Oxprenolol does not appear to modify significantly the circulatory response to arterial carbon dioxide tension.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/53.1.19