Non-invasive diagnosis of ischaemic heart failure using 64-slice computed tomography

Aims We evaluated the accuracy of 64-slice computed tomography (CT) to identify ischaemic aetiology of heart failure (IHF). Methods and results Ninety-three consecutive patients in sinus rhythm with dilated cardiomyopathy but without suspicion of coronary artery disease (CAD) were enrolled when admi...

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Published in:European heart journal 2008-09, Vol.29 (17), p.2133-2140
Main Authors: Ghostine, Saïd, Caussin, Christophe, Habis, Michel, Habib, Yacoub, Clément, Chaoui, Sigal-Cinqualbre, Anne, Angel, Claude-Yves, Lancelin, Bernard, Capderou, André, Paul, Jean-François
Format: Article
Language:English
Subjects:
Aged
Angiography
Calcinosis - diagnostic imaging
Cardiomyopathy
Cardiomyopathy, Dilated - diagnostic imaging
Cardiomyopathy, Dilated - etiology
Computed tomography
Coronary Angiography - methods
Coronary Stenosis - diagnostic imaging
Female
Heart failure
Heart Failure - diagnostic imaging
Humans
Male
Middle Aged
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
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Summary:Aims We evaluated the accuracy of 64-slice computed tomography (CT) to identify ischaemic aetiology of heart failure (IHF). Methods and results Ninety-three consecutive patients in sinus rhythm with dilated cardiomyopathy but without suspicion of coronary artery disease (CAD) were enrolled when admitted for angiography. Accuracy of CT to detect significant stenosis (>50% lumen narrowing) was compared with quantitative coronary angiography. IHF was defined as a significant stenosis on left main or proximal left anterior descending artery or two or more vessels. Forty-three out of 1395 segments (3%) were heavily calcified and excluded. CT correctly assessed 103 of 142 (73%) significant stenosis and identified 46 of 50 (92%) patients without and 42 of 43 (98%) patients with CAD, 60 of 62 (97%) patients without and 28 of 31 (90%) patients with IHF. Overall, accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of CT for identifying CAD by segment was 96, 73, 99, 92, and 97%, respectively; by patient was 95, 98, 92, 91, and 98%, respectively; and for identifying IHF was 95, 90, 97, 93, and 95%, respectively. Conclusion Non-invasive 64-slice CT assessment of the extent of CAD may offer a valid alternative to angiography for the diagnosis of IHF.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehn072