Synergistic Cancer Therapeutic Effects of Locally Delivered Drug and Heat Using Multifunctional Nanoparticles

Doxorubicin‐loaded PEG‐PLGA‐Au half‐shell nanoparticles provide multifunctions, such as photothermal treatment, photothermally controlled drug delilvery, and in vivo optical imaging. In addition, the combined doxorubicin and photothermal treatments using these multifunctional nanoparticles show syne...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2010-09, Vol.22 (36), p.4049-4053
Main Authors: Lee, Sun-Mi, Park, Huiyul, Yoo, Kyung-Hwa
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Cell Line, Tumor
chemo-photothermal therapy
Contrast Media - chemistry
Doxorubicin - chemistry
Doxorubicin - pharmacology
Doxorubicin - therapeutic use
Drug Carriers - chemistry
Female
Gold - chemistry
Hot Temperature - therapeutic use
Humans
in vivo imaging
Lactic Acid - chemistry
local delivery of drug/heat
Mice
Molecular Imaging
multifunctional nanoparticle
Nanoparticles - chemistry
NIR resorance
Polyethylene Glycols - chemistry
Polyglycolic Acid - chemistry
Tumor Burden - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Doxorubicin‐loaded PEG‐PLGA‐Au half‐shell nanoparticles provide multifunctions, such as photothermal treatment, photothermally controlled drug delilvery, and in vivo optical imaging. In addition, the combined doxorubicin and photothermal treatments using these multifunctional nanoparticles show synergistic therapeutic effects.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201001040