NEW ANTHRACYCLINE GLYCOSIDES FROM MICROMONOSPORA: II. ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES

Four glycosides, designated A, B, C and D, are the main components of the anthracycline complex produced by cultures of Micromonospora sp. nov. They were extracted by solvent partition, separated by column chromatography and characterized by chemical and physical methods as 11-deoxy analogues of dau...

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Bibliographic Details
Published in:Journal of antibiotics 1980, Vol.33(12), pp.1468-1473
Main Authors: CASSINELLI, GIUSEPPE, MATTEO, FRANCO DI, FORENZA, SALVATORE, RIPAMONTI, MARIA CLARA, RIVOLA, GIOVANNI, ARCAMONE, FEDERICO, MARCO, AURELIO DI, CASAZZA, ANNA MARIA, SORANZO, CARLA, PRATESI, GRAZIELLA
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic
Bacteria - drug effects
Cell Survival - drug effects
Cells, Cultured
Chemical Phenomena
Chemistry
Chemistry, Physical
Drug Resistance, Microbial
Glycosides - biosynthesis
Glycosides - isolation & purification
Glycosides - pharmacology
Humans
Lung - embryology
Mice
Micromonospora - metabolism
Naphthacenes - biosynthesis
Naphthacenes - isolation & purification
Naphthacenes - pharmacology
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Summary:Four glycosides, designated A, B, C and D, are the main components of the anthracycline complex produced by cultures of Micromonospora sp. nov. They were extracted by solvent partition, separated by column chromatography and characterized by chemical and physical methods as 11-deoxy analogues of daunorubicin. Among these new anthracyclines, displaying antibacterial and cytotoxic activity in vitro, 11-deoxydaunorubicin and 11-deoxydoxorubicin are also active against P388 leukemia in mice.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.33.1468