Streptococcus pneumoniae Colonization, Bacteremia, and Immune Response among Persons with Human Immunodeficiency Virus Infection

Although invasive pneumococcal infections are common among men infected with human immunodeficiency virus (HIV), the prevalence of pharyngeal colonization with Streptococcus pneumoniae was not significantly different among HIV-infected patients (8 [14%] of 56) and HIV-seronegative men (9 [9%] of 99)...

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Bibliographic Details
Published in:The Journal of infectious diseases 1993-01, Vol.167 (1), p.49-56
Main Authors: Janoff, Edward N. J, O'Brien, James, Thompson, Patricia, Ehret, Josephine, Meiklejohn, Gordon, Duvall, Gordon, Douglas, John M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS
AIDS/HIV
Antibodies
Bacteremia
Biological and medical sciences
Blood
Blood Bactericidal Activity
CD4-Positive T-Lymphocytes
HIV
HIV infections
HIV Infections - complications
HIV Infections - immunology
HIV Infections - microbiology
human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Leukocyte Count
Major Articles
Male
Medical sciences
Middle Aged
Pharynx - microbiology
Pneumococcal Infections - complications
Pneumococcal Infections - immunology
Pneumococcal Infections - microbiology
Pneumococcal pneumonia
Polysaccharides
Predisposing factors
Risk Factors
Sepsis - complications
Sepsis - immunology
Sepsis - microbiology
Streptococcus pneumoniae
Streptococcus pneumoniae - isolation & purification
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Summary:Although invasive pneumococcal infections are common among men infected with human immunodeficiency virus (HIV), the prevalence of pharyngeal colonization with Streptococcus pneumoniae was not significantly different among HIV-infected patients (8 [14%] of 56) and HIV-seronegative men (9 [9%] of 99) attending a sexually transmitted disease clinic. Sixteen HIV-infected men (mean CD4+ Tcell count, 132 ± 37/µL) developed pneumococcal bacteremia, accounting for 13.6% of 117 total cases and 42% of 38 cases in men 16-55 years old. Serum killing activity, a measure of functional humoral response to S. pneumoniae, was lower in 4 (67%) of 6 acute sera and 6 (54%) of 11 convalescent sera from bacteremic HIV-infected patients when compared with baseline sera of 7 HIV-seronegative healthy subjects. These findings suggest that the high rates of pneumococcal bacteremia among HIV-infected patients may be associated with low numbers of CD4+ T cells and impaired humoral responses to S. pneumoniae rather than to increased exposure to the organism.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/167.1.49