Atrial natriuretic factor and arginine vasopressin production in tumor cell lines from patients with lung cancer and their relationship to serum sodium

• Published in: Cancer research (Chicago, Ill.) Ill.), 1993, Vol.53 (1), p.67-74
• Main Authors: GROSS, A. J, STEINBERG, S. M, JOHNSON, B. E, REILLY, J. G, BLISS, D. P, BRENNAN, J, PHONG TRAM LE, SIMMONS, A, PHELPS, R, MULSHINE, J. L, IHDE, D. C
• Format: Article
• Language: English
• Subjects: Arginine Vasopressin - biosynthesis; Arginine Vasopressin - immunology; Atrial Natriuretic Factor - biosynthesis; Atrial Natriuretic Factor - immunology; Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - blood; Carcinoma, Non-Small-Cell Lung - complications; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Small Cell - blood; Carcinoma, Small Cell - complications; Carcinoma, Small Cell - metabolism; Humans; Hyponatremia - blood; Hyponatremia - etiology; Hyponatremia - metabolism; Inappropriate ADH Syndrome - blood; Inappropriate ADH Syndrome - etiology; Inappropriate ADH Syndrome - metabolism; Lung Neoplasms - blood; Lung Neoplasms - complications; Lung Neoplasms - metabolism; Medical sciences; Pneumology; Prognosis; Radioimmunoassay; Ribonucleases; RNA, Messenger - genetics; Sodium - blood; Tumor Cells, Cultured; Tumors of the respiratory system and mediastinum
• ISSN: 0008-5472; 1538-7445

Patients with lung cancer (n = 263) were studied to determine the relationship among ectopic production of atrial natriuretic factors (ANF) and arginine vasopressin (AVP), serum sodium, and patient outcome. Of 133, 21 (16%) patients with small cell lung cancer (SCLC) had hyponatremia (serum sodium, < 130 mmol/liter), compared to none of 130 (0%) patients with non-small cell lung cancer (P < 0.0001). Patients with extensive-stage SCLC and hyponatremia had shorter survival than patients with extensive stage SCLC and normal serum sodium values (P = 0.012). Of the 11 hyponatremic patients with SCLC and tumor cell lines available for study, 9 produced ANF mRNA, 7 of 11 produced AVP mRNA, and 5 of 11 produced both ANF mRNA and AVP mRNA. All 11 cell lines produced either ANF mRNA and ANF peptide or AVP mRNA and AVP peptide, or both. The quantity of AVP peptide in the tumor cell lines was more closely associated with hyponatremia in the patients (P = 0.0026, r2 = 0.28) than was the production of ANF peptide (P = 0.066, r2 = 0.12), although neither association was strong. All tumor cell lines studied from SCLC patients with hyponatremia produce ANF and/or AVP mRNA and peptides.