Association with TP53 codon 72 polymorphism and the risk of non‐Hodgkin lymphoma

Polymorphism of TP53 Arg72Pro is associated with many different cancers[1-4]. Few studies have investigated its role in the susceptibility to non-Hodgkin lymphoma (NHL) [5,6]. To examine the association between this polymorphism and NHL risk, we conducted a Korean large-scale, population-based case-...

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Bibliographic Details
Published in:American journal of hematology 2010-10, Vol.85 (10), p.822-824
Main Authors: Kim, Hee Nam, Yu, Li, Kim, Nan Young, Lee, Il‐Kwon, Kim, Yeo‐Kyeoung, Yang, Deok‐Hwan, Lee, Je‐Jung, Shin, Min–Ho, Park, Kyeong‐Soo, Choi, Jin‐Su, Kim, Hyeoung‐Joon
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Codon - genetics
Female
Gene Frequency
Genes, p53
Genetic Predisposition to Disease
Genotype
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Large B-Cell, Diffuse - epidemiology
Lymphoma, Large B-Cell, Diffuse - genetics
Lymphoma, Non-Hodgkin - epidemiology
Lymphoma, Non-Hodgkin - genetics
Male
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide
Republic of Korea - epidemiology
Risk
Tumor Suppressor Protein p53 - genetics
Young Adult
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Summary:Polymorphism of TP53 Arg72Pro is associated with many different cancers[1-4]. Few studies have investigated its role in the susceptibility to non-Hodgkin lymphoma (NHL) [5,6]. To examine the association between this polymorphism and NHL risk, we conducted a Korean large-scale, population-based case-control study (945 cases and 1,700 controls). The TP53 72CC genotype was associated with increased risk of NHL (P 5 0.04) and diffuse large B-cell lymphoma (P 5 0.04). Our findings provide evidence that the TP53 Arg72Pro is associated with an increased risk of NHL in Korea.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.21834