Decreased Default Mode Neural Modulation With Age in Schizophrenia

Objective Previous studies have shown that patients with schizophrenia have less modulation of the task-positive and default mode neural networks during novelty detection. The diminished modulation may be interpreted as less functional activation of the task-positive network and less functional deac...

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Bibliographic Details
Published in:The American journal of geriatric psychiatry 2010-10, Vol.18 (10), p.897-907
Main Authors: Abbott, Christopher C., M.D., M.S, Il Kim, Dae, B.S, Sponheim, Scott R., Ph.D, Bustillo, Juan, M.D, Calhoun, Vince D., Ph.D
Format: Article
Language:English
Subjects:
Adult
Age Factors
Brain - physiopathology
duration of illness
Female
fMRI
Humans
independent component analysis
Internal Medicine
Magnetic Resonance Imaging - methods
Male
Middle Aged
Neural Pathways - physiopathology
Principal Component Analysis
Psychomotor Performance - physiology
Schizophrenia
Schizophrenia - physiopathology
Severity of Illness Index
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Summary:Objective Previous studies have shown that patients with schizophrenia have less modulation of the task-positive and default mode neural networks during novelty detection. The diminished modulation may be interpreted as less functional activation of the task-positive network and less functional deactivation of the default mode network. The relationship between network modulation and age has not been assessed in patients with a long duration of illness. Method Seventeen patients with schizophrenia (age range, from 34 to 60 years) with minimum disorder duration of 15 years and 28 demographically similar comparison subjects (age range, from 36 to 58 years) from the Mind Clinical Imaging Consortium database completed the auditory oddball discrimination task. Independent component analysis identified temporally cohesive but spatially distributed neural networks. Results Group membership (F[1, 41] = 7.17, p = 0.011) and the interaction of group and age (F[1, 41] = 6.92, p = 0.012) affected the modulation of the anterior default mode network. Duration of illness was also significantly related to the modulation of the anterior default mode network (t[2, 15] = 2.24, p
ISSN:1064-7481
1545-7214
DOI:10.1097/JGP.0b013e3181e9b9d9