Epidemiology of Cercopithecine Herpesvirus 1 (B Virus) Infection and Shedding in a Large Breeding Cohort of Rhesus Macaques

The epidemiology of B virus infection in a large (n = 157) cohort of rhesus macaques at the California Regional Primate Research Center was evaluated prospectively from September 1989 through January 1991 by serial physical examinations, a behavioral substudy (n = 51), and repeated diagnostic testin...

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Bibliographic Details
Published in:The Journal of infectious diseases 1993-02, Vol.167 (2), p.257-263
Main Authors: Weigler, Benjamin J., Hird, David W., Hilliard, Julia K., Lerche, Nicholas W., Roberts, Jeffrey A., Scott, Linda M.
Format: Article
Language:English
Subjects:
Animal viral diseases
Animals
Antibodies, Viral - blood
Behavior, Animal
Biological and medical sciences
Breeding
Breeding seasons
Cercopithecine herpesvirus 1
Conjunctiva - microbiology
Epidemiology
Female
Female animals
Genitalia
Genitalia - microbiology
Herpesviridae Infections - epidemiology
Herpesviridae Infections - veterinary
Herpesvirus 1, Cercopithecine - immunology
Herpesvirus 1, Cercopithecine - isolation & purification
Incidence
Infections
Infectious diseases
Lesions
Macaca
Macaca mulatta
Major Articles
Male
Medical sciences
Monkey Diseases - epidemiology
Monkeys
Mouth Mucosa - microbiology
Proportional Hazards Models
Prospective Studies
Recurrence
Seasons
Sexual Behavior, Animal
Viral diseases
Virus Shedding
Viruses
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Description
Summary:The epidemiology of B virus infection in a large (n = 157) cohort of rhesus macaques at the California Regional Primate Research Center was evaluated prospectively from September 1989 through January 1991 by serial physical examinations, a behavioral substudy (n = 51), and repeated diagnostic testing. Half were B virus antibody-positive at baseline; subsequently, incident cases of infection were documented through serology alone (42) or with virus isolation (5). Eight recurrent infections and a single symptomatic (primary) case were observed. Risk of Bvirus infection increased as monkeys aged, with few >3 years old remaining uninfected. Postpubertal monkeys and those entering sexual adolescence (2–3 years) were at greatest risk, although wounding by cagemates and breeding history (for females) were both significant predictors of time to infection. B virus was isolated from oral or conjunctival and genital tissues in equal proportions. Transmission occurred only during the breeding season, possibly coinciding with an elevation in social stressors in the population.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/167.2.257