L1, β-catenin, and E-cadherin expression in patients with colorectal cancer: Correlation with clinicopathologic features and its prognostic significance

Objective Currently, there are no clinically used/routine biomarkers that accurately predict whether colorectal cancer (CRC) patients will or will not respond to adjuvant chemotherapy. The aim of this study was to investigate L1, β‐catenin, and E‐cadherin expression in patients with CRC and their re...

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Published in:Journal of surgical oncology 2010-10, Vol.102 (5), p.433-442
Main Authors: Fang, Qing-Xia, Lü, Liang-Zhong, Yang, Bo, Zhao, Zhong-Sheng, Wu, Yue, Zheng, Xiao-Chun
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - metabolism
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adolescent
Adult
Aged
beta Catenin - metabolism
Biomarkers, Tumor - metabolism
Cadherins - metabolism
Chemotherapy, Adjuvant
colorectal cancer
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
E-cadherin
Female
Humans
Male
Middle Aged
Multivariate Analysis
Neural Cell Adhesion Molecule L1 - metabolism
Prognosis
Retrospective Studies
survival
Survival Rate
Treatment Outcome
Young Adult
β-catenin
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Summary:Objective Currently, there are no clinically used/routine biomarkers that accurately predict whether colorectal cancer (CRC) patients will or will not respond to adjuvant chemotherapy. The aim of this study was to investigate L1, β‐catenin, and E‐cadherin expression in patients with CRC and their relationship to tumor progression, and to identify patients who will respond to chemotherapy. Methods A total of 142 patients who underwent surgical treatment for CRC were chosen retrospectively. The samples from these patients were analyzed by immunohistochemistry. SPSS‐14 program package was used for statistical calculation. Results Expression of L1, β‐catenin, and E‐cadherin were found to be strongly associated with invasion and metastasis of CRC. Cox multivariate analysis results indicated that L1 expression and stage of Dukes could be considered as the independent prognostic factors for survival. Furthermore, our study found that the 5‐year survival rate was the significantly associated with the expression of L1, β‐catenin (normal and ectopic expression), and E‐cadherin for Dukes' stage B (P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.21537