Predicting risk for bisphosphonate-related osteonecrosis of the jaws: CTX versus radiographic markers

Background and objective The most common risk factor for bisphosphonate-related osteonecrosis of the jaws (BRONJ) is dentoalveolar surgery. It has been suggested that reduced serum C-terminal telopeptide (CTX) can determine the degree of osteoclast suppression and may predict the development of BRON...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2010-10, Vol.110 (4), p.509-516
Main Authors: Fleisher, Kenneth E., DDS, Welch, Garrett, Kottal, Shailesh, DDS, Craig, Ronald G., DMD, PhD, Saxena, Deepak, MS, PhD, Glickman, Robert S., DMD
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - diagnostic imaging
Biological and medical sciences
Bone Density Conservation Agents - adverse effects
Bones, joints and connective tissue. Antiinflammatory agents
Case-Control Studies
Cohort Studies
Collagen Type I - blood
Dentistry
Diphosphonates - adverse effects
Diseases of the osteoarticular system
Humans
Jaw Diseases - blood
Jaw Diseases - chemically induced
Jaw Diseases - diagnosis
Jaw Diseases - diagnostic imaging
Medical sciences
Osteonecrosis - blood
Osteonecrosis - chemically induced
Osteonecrosis - diagnosis
Osteonecrosis - diagnostic imaging
Otorhinolaryngology. Stomatology
Peptides - blood
Periodontal Ligament - diagnostic imaging
Periodontal Ligament - pathology
Pharmacology. Drug treatments
Predictive Value of Tests
Radiography, Dental - methods
Retrospective Studies
Risk Factors
Surgery
Tooth Extraction - adverse effects
Vascular bone diseases
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Summary:Background and objective The most common risk factor for bisphosphonate-related osteonecrosis of the jaws (BRONJ) is dentoalveolar surgery. It has been suggested that reduced serum C-terminal telopeptide (CTX) can determine the degree of osteoclast suppression and may predict the development of BRONJ after dentoalveolar surgery. Although there are many radiographic appearances associated with BRONJ, there are little data that describes changes preceding dentoalveolar surgery. The objective of this retrospective study was: 1) to investigate if reduced serum CTX values (i.e.,
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2010.04.023