Clinical and Prognostic Effect of a Positive Granulocyte Scan in Infective Endocarditis

Thirty patients with clinical signs of infective endocarditis and pathologic echocardiographic findings indicating vegetations underwent scanning with ln-111 or Tc-99m hexamethylpropylene amineoxime (HMPAO) labeled granulocytes. Blood cultures were positive in 60% of the patients. The other cases we...

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Bibliographic Details
Published in:Clinical nuclear medicine 1993-01, Vol.18 (1), p.35-39
Main Authors: BORST, U, BECKER, W, MAISCH, B, BÖRNER, W, KOCHSIEK, K
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood cells
Echocardiography
Endocarditis, Bacterial - diagnostic imaging
Endocarditis, Bacterial - epidemiology
Female
Granulocytes
Humans
Indium Radioisotopes
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Organometallic Compounds
Organotechnetium Compounds
Oximes
Oxyquinoline - analogs & derivatives
Predictive Value of Tests
Prognosis
Radionuclide Imaging
Radionuclide investigations
Sensitivity and Specificity
Technetium Tc 99m Exametazime
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Summary:Thirty patients with clinical signs of infective endocarditis and pathologic echocardiographic findings indicating vegetations underwent scanning with ln-111 or Tc-99m hexamethylpropylene amineoxime (HMPAO) labeled granulocytes. Blood cultures were positive in 60% of the patients. The other cases were negative as a result of antibiotic pretreatment. The results of scintigraphy were correlated with the subsequent clinical course, and in 20 cases with data obtained by histologic examination of the valves. With regard to the degree of the inflammatory process, the nuclear medical procedure provided the following resultstrue-positive in 6 cases, false-positive in 1 case, true-negative in 19 cases, and false-negative in 3 cases. In this study, positive granulocyte scans correlate with high activity of the inflammatory process and predict a poor prognosis for the patients concerned.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199301000-00008