Nitric oxide synthase activities in human myocardium

Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant activity of inducible enzyme was accompanied by a low activity of the constitutive NO synthase. Thus, the myocardium...

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Bibliographic Details
Published in:The Lancet (British edition) 1993-01, Vol.341 (8837), p.84-85
Main Authors: de Belder, A.J., Why, H.J.F., Richardson, P.J., Bucknall, C.A., Martin, J.F., Radomski, M.W., Salas, E., Moncada, S.
Format: Article
Language:English
Subjects:
Amino Acid Oxidoreductases - metabolism
Animals
Biological and medical sciences
Calcium - metabolism
Cardiology. Vascular system
Cardiomyopathy, Dilated - enzymology
Cardiovascular disease
Enzyme Induction
Enzymes
Heart
Humans
Medical research
Medical sciences
Myocarditis. Cardiomyopathies
Myocardium - enzymology
Nitric oxide
Nitric Oxide Synthase
Rats
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Summary:Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant activity of inducible enzyme was accompanied by a low activity of the constitutive NO synthase. Thus, the myocardium has the capacity to express both NO synthases. NO may have a physiological as well as a pathological role in the human myocardium. Lancet 1993; 341: 84-85.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(93)92559-C