MALIOXAMYCIN, A NEW ANTIBIOTIC WITH SPHEROPLAST-FORMING ACTIVITY: I. PRODUCING ORGANISM, FERMENTATION, ISOLATION AND CHARACTERIZATION

Strain No. 15748, identified as Streptomyces lydicus, produced a new antibiotic malioxamycin. Malioxamycin is a water-soluble, amphoteric antibiotic with low molecular weight, having a valine and a malic acid moieties in its structure. It gave a positive ninhydrin and ferric chloride reactions. Mali...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1980, Vol.33(11), pp.1213-1219
Main Authors: TAKEUCHI, MICHIKO, INUKAI, MASATOSHI, ENOKITA, RYUZO, IWADO, SEIGO, TAKAHASHI, SHUJI, ARAI, MAMORU
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Chemical Phenomena
Chemistry, Physical
Culture Media
Dipeptides - biosynthesis
Dipeptides - isolation & purification
Dipeptides - pharmacology
Drug Resistance, Microbial
Escherichia coli - cytology
Escherichia coli - drug effects
Fermentation
Peptides
Spheroplasts - drug effects
Streptomyces - classification
Streptomyces - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Strain No. 15748, identified as Streptomyces lydicus, produced a new antibiotic malioxamycin. Malioxamycin is a water-soluble, amphoteric antibiotic with low molecular weight, having a valine and a malic acid moieties in its structure. It gave a positive ninhydrin and ferric chloride reactions. Malioxamycin inhibited the growth of some Gram-negative bacteria by acting on peptidoglycan synthesis in the cell wall and produced spheroplasts from those sensitive bacteria.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.33.1213