Malignant epithelioid hemangioendothelioma arising in an intramuscular lipoma

Background. A malignant epithelioid hemangioendothelioma (EH) developed within a peripheral intramuscular lipoma. It was seen as a painful calf mass. At the time of biopsy and enbloc resection, lung metastases were observed. Methods. Radiologic, histologic, immunohistochemical, and ultrastructural f...

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Bibliographic Details
Published in:Cancer 1993-02, Vol.71 (3), p.764-768
Main Authors: Zagzag, David, Yang, Grace, Seidman, Irving, Lusskin, Ralph
Format: Article
Language:English
Subjects:
angiogenesis
Biological and medical sciences
Diseases of the osteoarticular system
epithelioid
Epithelium - pathology
Female
hemangioendothelioma
Hemangioendothelioma - pathology
Hemangioendothelioma - secondary
Humans
intramuscular lipoma
Leg
Lipoma - pathology
Lipoma - secondary
lung metastases
malignant
Medical sciences
Middle Aged
Muscular Diseases - pathology
neoplasm
Tumors of striated muscle and skeleton
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Description
Summary:Background. A malignant epithelioid hemangioendothelioma (EH) developed within a peripheral intramuscular lipoma. It was seen as a painful calf mass. At the time of biopsy and enbloc resection, lung metastases were observed. Methods. Radiologic, histologic, immunohistochemical, and ultrastructural features of the neoplasm are described, and the literature pertaining to EH is reviewed. Results. The features of this tumor permitted its classification as a malignant EH. Conclusions. This case illustrates the potential for aggressive behavior in an EH, often considered to be a low‐grade malignant neoplasm. Because such tumors can metastasize, they should be removed with wide margins whenever possible. This malignant neoplasm was located within a benign intramuscular lipoma, demonstrating the diagnostic problem that may exist in such a complex lesion.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19930201)71:3<764::AID-CNCR2820710319>3.0.CO;2-U