Hyposomatomedinemia in Quadriplegic Men

Many studies have shown that vigorous exercise acutely stimulates growth hormone (GH) release but the relative contribution of daily physical activity to maintaining the GH/somatomedin C (SmC) axis is not known. It has been reported that basal and post-exercise plasma SmC values are higher in physic...

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Bibliographic Details
Published in:The American journal of the medical sciences 1993-02, Vol.305 (2), p.95-100
Main Authors: Shetty, Kaup R., Sutton, Carl H., Mattson, Dale E., Rudman, Daniel
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aging
Biological and medical sciences
Cerebrospinal fluid. Meninges. Spinal cord
Dependency
Exercise - physiology
Growth hormone
Growth Hormone - metabolism
Humans
Insulin-Like Growth Factor I - deficiency
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factor-I
Lean body mass
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Physical exercise
Quadriplegia
Quadriplegia - blood
Quadriplegia - physiopathology
Skeletal muscle
Somatomedin-C
Spinal Cord Injuries - complications
Spinal Cord Injuries - physiopathology
Spinal cord injury
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Summary:Many studies have shown that vigorous exercise acutely stimulates growth hormone (GH) release but the relative contribution of daily physical activity to maintaining the GH/somatomedin C (SmC) axis is not known. It has been reported that basal and post-exercise plasma SmC values are higher in physically conditioned young men than in sedentary men of similar age. To assess the effect of severe inactivity on the plasma SmC level, basal concentrations of this hormone were measured in patients with quadriplegia (QP) resulting from spinal cord injury (SCI). Venous blood samples were obtained after overnight fast in 41 QP men, ages 24–66, and compared with 119 healthy men of similar ages. Nonparametric analysis of variance showed SmC to be significantly lower in QP than in healthy men (p
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-199302000-00006