Distribution of DYZ2 repetitive sequences on the human Y chromosome

The distribution of the 2000 copies of the Y-specific repetitive family DYZ2 is controversial since previous reports have mapped these sequences to different sites of the Yqh region. In this work, we have performed non-radioactive in situ hybridization of a cloned DYZ2 fragment at higher stringency...

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Bibliographic Details
Published in:Human genetics 1993, Vol.90 (5), p.572-574
Main Authors: LUDENA, P, FERNANDEZ-PIQUERAS, J, SENTIS, C
Format: Article
Language:English
Subjects:
Azacitidine
Biological and medical sciences
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
distribution
DNA - analysis
Fundamental and applied biological sciences. Psychology
Genetic Techniques
Genetics of eukaryotes. Biological and molecular evolution
Heterochromatin
Human
Humans
In Situ Hybridization
Male
man
Multigene Family
repeated sequence
Repetitive Sequences, Nucleic Acid
Y Chromosome
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Summary:The distribution of the 2000 copies of the Y-specific repetitive family DYZ2 is controversial since previous reports have mapped these sequences to different sites of the Yqh region. In this work, we have performed non-radioactive in situ hybridization of a cloned DYZ2 fragment at higher stringency conditions on 5-aza-cytidine-enlarged Y chromosomes; the results suggest a non-uniform distribution of these sequences, which are preferentially located at the proximal and distal parts of Yqh, including the C+/Q- heterochromatin at the boundary with the euchromatic region.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00217462