Augmentation of human natural killer cells by splenopentin analogs

Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg- d-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr ( 2), d-Lys-Lys-Glu-Val-Tyr ( 3), Arg-Lys-Gly-Val-Tyr ( 4), and Arg-Lys-Gln-Val-Tyr ( 5) have been examined for augmentation of human natural killer (NK) cell activity and...

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Bibliographic Details
Published in:FEBS letters 1993-02, Vol.317 (1), p.93-95
Main Authors: Rastogi, A., Singh, V.K., Biswas, S., Haq, W., Mathur, K.B., Agarwal, S.S.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Amino Acid Sequence
Biological and medical sciences
Cells, Cultured
FCS
foetal calf serum
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Immunomodulator
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
Lymphocyte Activation - drug effects
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
Molecular Sequence Data
natural killer cells
NK cells
NK. cell cytotoxicity
Peptide Fragments - pharmacology
PHA
phytohaemagglutinin
Splenopentin
T-cell transformation
Thymopoietin
Thymopoietins - pharmacology
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Summary:Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg- d-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr ( 2), d-Lys-Lys-Glu-Val-Tyr ( 3), Arg-Lys-Gly-Val-Tyr ( 4), and Arg-Lys-Gln-Val-Tyr ( 5) have been examined for augmentation of human natural killer (NK) cell activity and human T-cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(93)81498-O