EFFECT OF BARICITY ON SPINAL ANAESTHESIA WITH BUPIVACAINE

In a double-blind study of spinal anaesthesia with 0.5% bupivacaine 3 ml with no glucose, 5% glucose or 8% glucose all three solutions gave consistently good nerve blocks. The hyperbaric solutions (5% and 8% glucose) produced a greater cephalad spread and were suitable for lower abdominal surgery, w...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1981-03, Vol.53 (3), p.279-282
Main Authors: CHAMBERS, W.A., EDSTROM, H.H., SCOTT, D.B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anesthesia, Spinal
Bupivacaine - administration & dosage
Bupivacaine - pharmacology
Clinical Trials as Topic
Double-Blind Method
Female
Hemodynamics - drug effects
Humans
Middle Aged
Nerve Block
Solutions
Specific Gravity
Subarachnoid Space
Time Factors
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Description
Summary:In a double-blind study of spinal anaesthesia with 0.5% bupivacaine 3 ml with no glucose, 5% glucose or 8% glucose all three solutions gave consistently good nerve blocks. The hyperbaric solutions (5% and 8% glucose) produced a greater cephalad spread and were suitable for lower abdominal surgery, whereas the plain solution (no glucose) seldom affected the thoracic nerves. Cardiovascular changes were more marked with the hyperbaric solutions but only necessitated treatment on two occasions. The duration of block was not affected by baricity and was in the range 140–160 min.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/53.3.279