growth of cell culture-attenuated rinderpest virus in bovine lymphoblasts with B cell, CD4+ and CD8+ alpha/beta T cell and gamma/delta T cell phenotypes

Cloned bovine lymphoblastoid cell lines, transformed by the protozoan parasite Theileria parva were infected with cell culture-attenuated rinderpest virus vaccine. The virus grew readily in lymphoid B cells, CD4+ and CD8+ alpha/beta T cells and gamma/delta T cells producing new infectivity, viral an...

Full description

Saved in:
Bibliographic Details
Published in:Journal of general virology 1993-02, Vol.74 (2), p.305-309
Main Authors: Rossiter, P.B, Herniman, K.A.J, Gumm, I.D, Morrison, W.I
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - microbiology
Biological and medical sciences
Bovidae
Cattle
cell culture
Cells, Cultured
Culture Media
Fundamental and applied biological sciences. Psychology
genetic transformation
Immunophenotyping
Microbiology
Receptors, Antigen, T-Cell - analysis
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Rinderpest virus
Rinderpest virus - growth & development
T-Lymphocyte Subsets - microbiology
Theileria parva
Virology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cloned bovine lymphoblastoid cell lines, transformed by the protozoan parasite Theileria parva were infected with cell culture-attenuated rinderpest virus vaccine. The virus grew readily in lymphoid B cells, CD4+ and CD8+ alpha/beta T cells and gamma/delta T cells producing new infectivity, viral antigens, c.p.e. and total cell death. There did not appear to be a predilection for any particular phenotype of lymphoblast. The results imply that if the vaccine causes immunosuppression, it could do so through a variety of mechanisms.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-74-2-305